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Formula | C18H23N5NaO8P |
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Molecular Weight | 491.37 | CAS No. | 16980-89-5 | |
Solubility (25°C)* | In vitro | DMSO | 98 mg/mL (199.44 mM) | |
Water | 98 mg/mL (199.44 mM) | |||
Ethanol | 25 mg/mL (50.87 mM) | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
Description | Dibutyryl-cAMP (Bucladesine, dbcAMP) is a cell-permeable PKA activator by mimicing the action of endogenous cAMP. Dibutyryl-cAMP (Bucladesine) is also a phosphodiesterase (PDE) inhibitor. | ||
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Targets |
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In vitro | Dibutyryl-cAMP inhibits neuronal glucose uptake via PKA activation. [1] In cultured rat hepatocytes, Dibutyryl-cAMP inhibits inducible nitric oxide synthase expression and NF-kappaB-binding activity. [2] Dibutyryl-cAMP also suppress TNFalpha-induced hepatocyte apoptosis by inhibiting FADD up-regulation. [3] |
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In vivo | In a mouse model, bucladesine (600 nM/mouse, i.p.) reverses zinc chloride- and lead acetate-induced avoidance memory retention impairments. [4] |
Cell Assay: |
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Animal Study: |
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Activation of hepatic adenosine A1 receptor ameliorates MASH via inhibiting SREBPs maturation [ Cell Rep Med, 2024, 5(3):101477] | PubMed: 38508143 |
Jiao-tai-wan and its effective component-berberine improve diabetes and depressive disorder through the cAMP/PKA/CREB signaling pathway [ J Ethnopharmacol, 2024, 324:117829] | PubMed: 38296172 |
IL-6-Derived Autocrine Lactate Promotes Immune Escape of Uveal Melanoma [ Invest Ophthalmol Vis Sci, 2024, 65(3):37] | PubMed: 38551584 |
IL-6-Driven Autocrine Lactate Promotes Immune Escape of Uveal Melanoma [ Invest Ophthalmol Vis Sci, 2024, 65(3):37] | PubMed: 38551584 |
Host-to-graft propagation of inoculated α-synuclein into transplanted human induced pluripotent stem cell-derived midbrain dopaminergic neurons [ Regen Ther, 2024, 25:229-237] | PubMed: 38283940 |
Axonal Lysosomal Assays for Characterizing the Effects of LRRK2 G2019S [ Biology (Basel), 2024, 13(1)58] | PubMed: 38275734 |
Asynchronous microexon splicing of LSD1 and PHF21A during neurodevelopment [ bioRxiv, 2024, 2024.03.21.586181] | PubMed: 38562691 |
Balanced SET levels favor the correct enhancer repertoire during cell fate acquisition [ Nat Commun, 2023, 14(1):3212] | PubMed: 37270547 |
Balanced SET levels favor the correct enhancer repertoire during cell fate acquisition [ Nat Commun, 2023, 14(1):3212] | PubMed: 37270547 |
Probabilistic cell seeding and non-autofluorescent 3D-printed structures as scalable approach for multi-level co-culture modeling [ Mater Today Bio, 2023, 21:100706] | PubMed: 37435551 |
RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.