DG172 dihydrochloride

Catalog No.S0531 Batch:S053101

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Technical Data

Formula

C20H20BrN3.2ClH
Molecular Weight 455.22 CAS No. 1361504-77-9
Solubility (25°C)* In vitro DMSO 91 mg/mL (199.9 mM)
Water 44 mg/mL (96.65 mM)
Ethanol 23 mg/mL (50.52 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description DG-172 dihydrochloride is a novel PPARβ/δ-selective antagonist with the IC50 of 27 nM.
Targets
PPARβ/δ [1]
(in a competitive TR-FRET assay)
27 nM
In vitro

DG-172 dihydrochloride selectively inhibits the agonist-induced activity of PPARβ/δ, enhances transcriptional corepressor recruitment, and down-regulates transcription of the PPARβ/δ target gene Angptl4 in mouse myoblasts. [1]

Protocol (from reference)

Cell Assay:

[1]
  • Cell lines

    C2C12 mouse myoblasts

  • Concentrations

    0.01, 0.1, 1, 10, 100, 1000, 10000, 100000 nM

  • Incubation Time

    24 h

  • Method

    C2C12 mouse myoblasts are treated for 24 h with DG-172 at the indicated concentration, and RNA is analyzed by RT-qPCR.

Selleck's DG172 dihydrochloride has been cited by 1 publication

ATRA-mediated-crosstalk between stellate cells and Kupffer cells inhibits autophagy and promotes NLRP3 activation in acute liver injury [ Cell Signal, 2022, 93:110304] PubMed: 35278669

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.