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Technical Data
| Formula | C23H32N6O6S2 |
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| Molecular Weight | 552.67 | CAS No. | 147221-93-0 | |
| Solubility (25°C)* | In vitro | DMSO | 100 mg/mL (180.93 mM) | |
| Ethanol | 4 mg/mL (7.23 mM) | |||
| Water | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Delavirdine Mesylate(U 90152 mesylate) is a mesylate salt form of delavirdine, which is a synthetic, non-nucleoside reverse transcriptase inhibitor. | ||
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| In vitro | Delavirdine is a potent and selective inhibitor of the HIV-1 RT (IC50=0.26 μM verus IC50s>440 μM for pol alpha and delta). Delavirdine has low cellular cytotoxicity, causing less than 8% reduction in human lymphocyte viability at 100 μM[1]. |
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| In vivo | Following single dose administration, the pharmacokinetics of delavirdine is nonlinear in rats, and appeared to be nonlinear in dogs. Systemic clearances in the dog, at a dose of 10 mg/kg, are approximately 20-fold lower than in the rat, whereas the clearances in monkeys are comparable to those in rats. Absolute p.o. bioavailabilities increase in the order monkey (30%) < rat (65%) < dog (100%) when equivalent i.v. and p.o. doses are administered[1]. |
Protocol (from reference)
Selleck's Delavirdine mesylate has been cited by 1 publication
| Unexpected similarity between HIV-1 reverse transcriptase and tumor necrosis factor binding sites revealed by computer vision [ J Cheminform, 2021, 13(1):90] | PubMed: 34814950 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.