Dehydroevodiamine

Catalog No.S3816 Batch:S381601

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Technical Data

Formula

C19H15N3O
Molecular Weight 301.34 CAS No. 67909-49-3
Solubility (25°C)* In vitro DMSO 19 mg/mL (63.05 mM)
 
 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Dehydroevodiamine (DHED), a constituent of Evodia rutaecarpa, has various biological effects such as hypotensive, negative chronotropic, ion channel depressant, inhibition of nitric oxide production and cerebral blood flow enhancing activities. Dehydroevodiamine inhibits LPS-induced iNOS, COX-2, prostaglandin E2 (PGE2) and nuclear factor-kappa B (NF-κB) expression in murine macrophage cells.
Targets
NF-κB [4] COX-2 [4] iNOS [4] PGE2 [4]
In vivo

The dose ranging study demonstrated that the volume of distribution and clearance are independent of the dose. The primary route of elimination for the drug is via metabolism[2]. i.v. administration of dehydroevodiamine elicited a slight but significant reduction in blood pressure and a marked decrease in heart rate[3].

Protocol (from reference)

Cell Assay:

[1]
  • Cell lines

    Cerebellar granule cells

  • Concentrations

    1-20 μM

  • Incubation Time

    9 days

  • Method

    The cells were exposed to various concentrations of dehydroevodiamine (1-20 μM) from 2 to 10 days in vitro. On the 10th day after plating, the viable cells were quantified.
Animal Study:

[2]
  • Animal Models

    Sprague-Dawley rats

  • Dosages

    1, 2.5, and 10 mg/kg

  • Administration

    intravenous infusion

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.