Decursin

Catalog No.S9264 Batch:S926401

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Technical Data

Formula

C19H20O5
Molecular Weight 328.36 CAS No. 5928-25-6
Solubility (25°C)* In vitro DMSO 66 mg/mL (200.99 mM)
 
 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Decursin is a pyranocoumarin obtained from the roots of Angelica gigas Nakai that exhibits anti-cancer, anti-inflammatory and neuroprotective activities.
In vitro

Decursin inhibits vasculogenesis in early tumor progression by suppression of endothelial progenitor cell differentiation and function.

Protocol (from reference)

Cell Assay:

[1]
  • Cell lines

    AC133+ cells

  • Concentrations

    0, 5, 20, 100 µM

  • Incubation Time

    7 days

  • Method

    Cells were treated with indicated concentrations of drug for 7 days.
Animal Study:

[1]
  • Animal Models

    C57BL/6J mice

  • Dosages

    4 mg/kg

  • Administration

    i.p.

Selleck's Decursin has been cited by 1 publication

Decursin Induces G1 Cell Cycle Arrest and Apoptosis through Reactive Oxygen Species-Mediated Endoplasmic Reticulum Stress in Human Colorectal Cancer Cells in In Vitro and Xenograft Models [ Int J Mol Sci, 2024, 25(18)9939] PubMed: 39337425

RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.