DDD107498

Catalog No.S0081 Batch:S008101

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Technical Data

Formula

C27H31FN4O2
Molecular Weight 462.56 CAS No. 1469439-69-7
Solubility (25°C)* In vitro DMSO 93 mg/mL (201.05 mM)
Water 93 mg/mL (201.05 mM)
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description DDD107498 (M-5717, DDD-498) is a P. falciparum translation elongation factor 2 inhibitor. DDD107498 exhibits a potent and novel spectrum of antimalarial activity against multiple life-cycle stages of the Plasmodium parasite.
In vitro

DDD107498 shows excellent activity against 3D7 parasites, with no toxic to human cells (MRC5 and Hep-G2 cells) at much higher concentrations.[1]
In vivo

There is a lag of about 24-48 h, during which time the effects of DDD107498 are reversible following wash-out. Rapid killing occurred after parasites when exposed to DDD107498 for more than 48 h.[1]

Protocol (from reference)

Cell Assay:

[1]
  • Cell lines

    3D7, HepG2 and MRC5 cells

  • Concentrations

    0.0001-10 μM

  • Incubation Time

    --

  • Method

    --
Animal Study:

[1]
  • Animal Models

    NOD-scid IL-2R_null mice

  • Dosages

    0.95 mg/kg/day

  • Administration

    p.o.

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.