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Technical Data
| Formula | C22H27Cl2N7O2S |
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| Molecular Weight | 524.47 | CAS No. | 854001-07-3 | |
| Solubility (25°C)* | In vitro | DMSO | 100 mg/mL (190.66 mM) | |
| Water | 42 mg/mL (80.08 mM) | |||
| Ethanol | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Preparing Stock Solutions
Biological Activity
| Description | Dasatinib hydrochloride (BMS-354825) is the hydrochloride salt form of dasatinib, an inhibitor that targets Abl, Src and c-Kit, with IC50 of <1 nM, 0.8 nM and 79 nM in cell-free assays, respectively. | ||||||||
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Protocol (from reference)
References
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Selleck's Dasatinib hydrochloride has been cited by 179 publications
| Downregulated SPESP1-driven fibroblast senescence decreases wound healing in aged mice [ Clin Transl Med, 2024, 14(5):e1660] | PubMed: 38764260 |
| Targeting of mutant-p53 and MYC as a novel strategy to inhibit oncogenic SPAG5 activity in triple negative breast cancer [ Cell Death Dis, 2024, 15(8):603] | PubMed: 39164278 |
| The ABL-MYC axis controls WIPI1-enhanced autophagy in lifespan extension [ Commun Biol, 2023, 6(1):872] | PubMed: 37620393 |
| The ABL-MYC axis controls WIPI1-enhanced autophagy in lifespan extension [ Commun Biol, 2023, 6(1):872] | PubMed: 37620393 |
| The ABL-MYC axis controls WIPI1-enhanced autophagy in lifespan extension [ Commun Biol, 2023, 6(1):872] | PubMed: 37620393 |
| THY1-mediated mechanisms converge to drive YAP activation in skin homeostasis and repair [ Nat Cell Biol, 2022, 24(7):1049-1063] | PubMed: 35798842 |
| MicroRNA-485-5p targets keratin 17 to regulate oral cancer stemness and chemoresistance via the integrin/FAK/Src/ERK/β-catenin pathway [ J Biomed Sci, 2022, 29(1):42] | PubMed: 35706019 |
| Local Elimination of Senescent Cells Promotes Bone Defect Repair during Aging [ ACS Appl Mater Interfaces, 2022, 10.1021/acsami.1c22138] | PubMed: 35014784 |
| The interactions between integrin α5β1 of liver cancer cells and fibronectin of fibroblasts promote tumor growth and angiogenesis [ Int J Biol Sci, 2022, 18(13):5019-5037] | PubMed: 35982891 |
| GSK3 inhibition circumvents and overcomes acquired lorlatinib resistance in ALK-rearranged non-small-cell lung cancer [ NPJ Precis Oncol, 2022, 6(1):16] | PubMed: 35301419 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.