Dasatinib hydrochloride

Catalog No.S5254 Batch:S525401

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Technical Data

Formula

C22H27Cl2N7O2S

Molecular Weight 524.47 CAS No. 854001-07-3
Solubility (25°C)* In vitro DMSO 100 mg/mL (190.66 mM)
Water 42 mg/mL (80.08 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Dasatinib hydrochloride (BMS-354825) is the hydrochloride salt form of dasatinib, an inhibitor that targets Abl, Src and c-Kit, with IC50 of <1 nM, 0.8 nM and 79 nM in cell-free assays, respectively.
Targets
Abl [1]
(Cell-free assay)
Src [1]
(Cell-free assay)
c-Kit (D816V) [1]
(Cell-free assay)
c-Kit (wt) [1]
(Cell-free assay)
0.6 nM 0.8 nM 37 nM 79 nM

Protocol (from reference)

Selleck's Dasatinib hydrochloride has been cited by 178 publications

Downregulated SPESP1-driven fibroblast senescence decreases wound healing in aged mice [ Clin Transl Med, 2024, 14(5):e1660] PubMed: 38764260
The ABL-MYC axis controls WIPI1-enhanced autophagy in lifespan extension [ Commun Biol, 2023, 6(1):872] PubMed: 37620393
The ABL-MYC axis controls WIPI1-enhanced autophagy in lifespan extension [ Commun Biol, 2023, 6(1):872] PubMed: 37620393
The ABL-MYC axis controls WIPI1-enhanced autophagy in lifespan extension [ Commun Biol, 2023, 6(1):872] PubMed: 37620393
THY1-mediated mechanisms converge to drive YAP activation in skin homeostasis and repair [ Nat Cell Biol, 2022, 24(7):1049-1063] PubMed: 35798842
MicroRNA-485-5p targets keratin 17 to regulate oral cancer stemness and chemoresistance via the integrin/FAK/Src/ERK/β-catenin pathway [ J Biomed Sci, 2022, 29(1):42] PubMed: 35706019
Local Elimination of Senescent Cells Promotes Bone Defect Repair during Aging [ ACS Appl Mater Interfaces, 2022, 10.1021/acsami.1c22138] PubMed: 35014784
The interactions between integrin α5β1 of liver cancer cells and fibronectin of fibroblasts promote tumor growth and angiogenesis [ Int J Biol Sci, 2022, 18(13):5019-5037] PubMed: 35982891
GSK3 inhibition circumvents and overcomes acquired lorlatinib resistance in ALK-rearranged non-small-cell lung cancer [ NPJ Precis Oncol, 2022, 6(1):16] PubMed: 35301419
Proteome-Wide Deconvolution of Drug Targets and Binding Sites by Lysine Reactivity Profiling [ Anal Chem, 2022, 10.1021/acs.analchem.1c05455] PubMed: 35147412

RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

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