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Technical Data
| Formula | C16H15N5.2ClH |
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| Molecular Weight | 350.25 | CAS No. | 28718-90-3 | |
| Solubility (25°C)* | In vitro | DMSO | 70 mg/mL (199.85 mM) | |
| Water | 10 mg/mL (28.55 mM) | |||
| Ethanol | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Preparing Stock Solutions
Biological Activity
| Description | DAPI Dihydrochloride (DAPI 2HCl) is a fluorescent dye that binds strongly to adenine–thymine-rich regions in DNA. |
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| In vitro | DAPI associates with the minor groove of double-stranded DNA, with a preference for the adenine-thymine clusters. Cells must be permeabilized and/or fixed for DAPI to enter the cell and to bind DNA. Fluorescence increases approximately 20-fold when DAPI is bound to double-stranded DNA. <sup><a class="sref" href="#s_ref">[1]</a></sup> |
Protocol (from reference)
Selleck's DAPI Dihydrochloride has been cited by 3 publications
| Delay tumor progression with the introduction of engineered impactive cells [ Research Square, 2023, 10.21203/rs.3.rs-2641539/v1] | PubMed: none |
| Multiplexed imaging of tumor immune microenvironmental markers in locally advanced or metastatic non-small-cell lung cancer characterizes the features of response to PD-1 blockade plus chemotherapy [ Cancer Commun (Lond), 2022, 42(12):1331-1346] | PubMed: 36331328 |
| An Episomal CRISPR/Cas12a System for Mediating Efficient Gene Editing [ Life (Basel), 2021, 11(11)1262] | PubMed: 34833137 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.