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Technical Data
| Formula | C14H16ClN3O4S2 |
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| Molecular Weight | 389.88 | CAS No. | 2259-96-3 | |
| Solubility (25°C)* | In vitro | DMSO | 78 mg/mL (200.06 mM) | |
| Ethanol | 19 mg/mL (48.73 mM) | |||
| Water | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Cyclothiazide is a positive allosteric modulator of ionotropic α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)-type glutamate receptors with critical roles in neurological development and function. | |
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| In vitro | Cyclothiazide is known to produce a fast inhibition of AMPA receptor desensitization and a much slower potentiation of the AMPA current[1]. |
Protocol (from reference)
Selleck's Cyclothiazide has been cited by 11 publications
| Engineered Cas9 variants bypass Keap1-mediated degradation in human cells and enhance epigenome editing efficiency [ Nucleic Acids Res, 2024, gkae761] | PubMed: 39228373 |
| STING Suppresses Mitochondrial VDAC2 to Govern RCC Growth Independent of Innate Immunity [ Adv Sci (Weinh), 2023, 10(3):e2203718] | PubMed: 36445063 |
| GINS1 promotes the proliferation and migration of glioma cells through USP15-mediated deubiquitination of TOP2A [ iScience, 2022, 25-9:104952] | PubMed: 36065190 |
| SPOP and OTUD7A Control EWS-FLI1 Protein Stability to Govern Ewing Sarcoma Growth [ Adv Sci (Weinh), 2021, e2004846] | PubMed: 34060252 |
| SPOPandOTUD7AControlEWS–FLI1Protein Stability to Govern Ewing Sarcoma Growth [ ADVANCED SCIENCE, 2021, 8(14)] | PubMed: None |
| Minimal mitochondrial respiration is required to prevent cell death by inhibition of mTOR signaling in CoQ-deficient cells [ Cell Death Discov, 2021, 7(1):201] | PubMed: 34349107 |
| TRIM16 overexpression inhibits the metastasis of colorectal cancer through mediating Snail degradation [ Exp Cell Res, 2021, 406(1):112735] | PubMed: 34265287 |
| RNF144A functions as a tumor suppressor in breast cancer through ubiquitin ligase activity-dependent regulation of stability and oncogenic functions of HSPA2. [ Cell Death Differ, 2020, 27(3):1105-1118] | PubMed: 31406303 |
| Histone Acetyltransferase (HAT) P300/CBP Inhibitors Induce Synthetic Lethality in PTEN-Deficient Colorectal Cancer Cells Through Destabilizing AKT [ Int J Biol Sci, 2020, 25;16(11):1774-1784] | PubMed: 32398948 |
| Design and synthesis of selective degraders of EGFRL858R/T790M mutant. [ Eur J Med Chem, 2020, 15;192:112199] | PubMed: 32171162 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.