Cyclo(RGDyK)

Catalog No.S7844 Batch:S784404

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Technical Data

Formula

C31H43F6N9O12
Molecular Weight 847.72 CAS No. 250612-42-1
Solubility (25°C)* In vitro DMSO 100 mg/mL (117.96 mM)
Water 100 mg/mL (117.96 mM)
Ethanol 100 mg/mL (117.96 mM)
In vivo (Add solvents to the product individually and in order)
5% DMSO 95% Corn oil
2.5mg/ml
5%DMSO 40%PEG300 5%Tween80 50%ddH2O
5.0mg/ml
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Cyclo(RGDyK) is a potent and selective αVβ3 integrin inhibitor with IC50 of 20 nM.
Targets
αVβ3 integrin [1]
20 nM
In vitro Cyclo(RGDyK) shows high affinity and selectivity for αVβ3 over αVβ5 and αIIbβ3. [1] Cyclo(RGDyK)-conjugated micelles (TPM) facilitated the cell-specific uptake of DiI into B16-F10 cells and HUVECs via integrin-mediated endocytosis compared with Cyclo(RGDyK) -free micelles (NPM). [2]
In vivo In apoE−/− mice, Cyclo(RGDyK) (1 nmol, i.v.) inhibits the increase of αVβ3 integrin expression in the intima of the left stenotic carotid artery. [2]

Protocol (from reference)

Customer Product Validation

Data from [Data independently produced by , , Carcinogenesis, 2018, doi:10.1093/carcin/bgy146]

Selleck's Cyclo(RGDyK) has been cited by 13 publications

Egfl6 promotes ovarian cancer progression by enhancing the immunosuppressive functions of tumor-associated myeloid cells [ J Clin Invest, 2024, e175147] PubMed: 39312740
Regulation of the integrin αVβ3- actin filaments axis in early osteogenic differentiation of human mesenchymal stem cells under cyclic tensile stress [ Cell Commun Signal, 2023, 10.1186/s12964-022-01027-7] PubMed: 37904190
Molecular signaling from microglia impacts macroglia autophagy and neurons survival in glaucoma [ iScience, 2023, 26(6):106839] PubMed: 37250793
Integrin αVβ3 Signaling in the Progression of Osteoarthritis Induced by Excessive Mechanical Stress [ Inflammation, 2023, 46(2):739-751] PubMed: 36480128
Inhibition of Integrin αvβ3-FAK-MAPK signaling constrains the invasion of T-ALL cells [ Cell Adh Migr, 2023, 17(1):1-14] PubMed: 36944577
Inhibition of Integrin αvβ3-FAK-MAPK signaling constrains the invasion of T-ALL cells [ Cell Adhesion & Migration, 2023, 17(1)] PubMed: None
Integrin α2 and β1 Cross-Communication with mTOR/AKT and the CDK-Cyclin Axis in Hepatocellular Carcinoma Cells [ Cancers (Basel), 2022, 14(10)2430] PubMed: 35626034
Renal protection induced by physical exercise may be mediated by the irisin/AMPK axis in diabetic nephropathy [ Sci Rep, 2022, 12(1):9062] PubMed: 35641586
Regulation of the integrin αVβ3- actin filaments axis in early osteogenesis of human fibroblasts under cyclic tensile stress [ Stem Cell Res Ther, 2021, 12(1):523] PubMed: 34620239
M2 polarization of tumor-associated macrophages is dependent on integrin β3 via peroxisome proliferator-activated receptor-γ up-regulation in breast cancer. [ Immunology, 2020, 20] PubMed: 32311768

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.