CU-CPD107

Catalog No.S9937 Batch:S993701

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Technical Data

Formula

C16H21IN2O2
Molecular Weight 400.26 CAS No. 2573912-32-8
Solubility (25°C)* In vitro DMSO 80 mg/mL (199.87 mM)
Ethanol 80 mg/mL (199.87 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description CU-CPD107 is a selective, dual-activity small-molecule which demonstrated differential activity against the TLR8 agonists and ssRNA ligands. In the presence of R848, CU-CPD107 acts as a TLR8 signaling inhibitor (IC50=13.7 μM). In the presence of ssRNA, CU-CPD107 shows synergistic agonist activities, while CU-CPD107 alone is unable to influence TLR8 signaling.
Targets
TLR8 [1]
(in HEK-Blue hTLR8 cells)
13.7 μM
In vitro

CU-CPD107, a tetrasubstituted imidazole, inhibits R848-induced TLR8 signaling and shows unexpected synergistic agonist activities in the presence of ssRNA, while CU-CPD107 alone is unable to influence TLR8 signaling.[1]

Protocol (from reference)

Cell Assay:

[1]
  • Cell lines

    HEK-Blue cells, HEK-Blue hTLR cells, HEK-Blue Null1 cells

  • Concentrations

    0-100 µM

  • Incubation Time

    24 h

  • Method

    Cellular toxicity was assessed using the Roche Cell Proliferation Reagent WST1 per the manufacturer's recommendation. Briefly, WST1 was diluted 1:10 into cell-containing media and assayed with absorbance at 450 nm.

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.