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Technical Data
| Formula | C20H21N7O3 |
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| Molecular Weight | 407.43 | CAS No. | 1202402-40-1 | |
| Solubility (25°C)* | In vitro | DMSO | 81 mg/mL (198.8 mM) | |
| Water | Insoluble | |||
| Ethanol | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Preparing Stock Solutions
Biological Activity
| Description | Ciforadenant (CPI-444, V81444) is a potent and selective Adenosine A2A receptor antagonist. It binds to A2A receptors with a Ki of 3.54 nmol/L and demonstrates a greater than 50-fold selectivity for the A2A receptor over other adenosine receptor subtypes. | ||
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| Targets |
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| In vitro | CPI-444 restores T-cell activation in vitro[1]. |
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| In vivo | CPI-444 treatment resulted in a similar inhibition of tumor growth in the B16F10 melanoma (100 mg/kg) and RENCA renal cell cancer syngeneic models (10 mg/kg). It enhances T-cell activation in both the periphery and tumor microenvironment[1]. |
Protocol (from reference)
| Animal Study: |
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Selleck's Ciforadenant (CPI-444) has been cited by 2 publications
| A2AR-mediated CXCL5 upregulation on macrophages promotes NSCLC progression via NETosis [ Cancer Immunol Immunother, 2024, 73(6):108] | PubMed: 38642131 |
| Additive effect of CD73 inhibitor in colorectal cancer treatment with CDK4/6 inhibitor through regulation of PD-L1 [ Cell Mol Gastroenterol Hepatol, 2022, S2352-345X(22)00163-1] | PubMed: 35843546 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.