CP21R7

Catalog No.S7954 Batch:S795401

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Technical Data

Formula

C19H15N3O2
Molecular Weight 317.34 CAS No. 125314-13-8
Solubility (25°C)* In vitro DMSO 63 mg/mL (198.52 mM)
Ethanol 1 mg/mL (3.15 mM)
Water Insoluble
In vivo (Add solvents to the product individually and in order)
Clear solution
5% DMSO 95% Corn oil
0.39mg/ml Taking the 1 mL working solution as an example, add 50 μL of 7.8 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results. 
Clear solution
5%DMSO 40%PEG300 5%Tween80 50%ddH2O
3.15mg/ml Taking the 1 mL working solution as an example, add 50 μL of 63 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results. 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description CP21R7 is a potent and selective GSK-3β inhibitor that can potently activate canonical Wnt signalling.
Targets
GSK-3β [1]
(Cell-free assay)

Protocol (from reference)

Selleck's CP21R7 has been cited by 12 publications

Activation of the Wnt/β-catenin signalling pathway enhances exosome production by hucMSCs and improves their capability to promote diabetic wound healing [ J Nanobiotechnology, 2024, 22(1):373] PubMed: 38926800
Generating human artery and vein cells from pluripotent stem cells highlights the arterial tropism of Nipah and Hendra viruses [ Cell, 2022, 185(14):2523-2541.e30] PubMed: 35738284
Establishment and characterization of immortalized sweat gland myoepithelial cells [ Sci Rep, 2022, 12(1):7] PubMed: 34997030
Nanoprotein Interaction Atlas Reveals the Transport Pathway of Gold Nanoparticles across Epithelium and Its Association with Wnt/β-Catenin Signaling [ ACS Nano, 2021, 10.1021/acsnano.1c06452] PubMed: 34672537
Endothelial Progenitor Cells Produced From Human Pluripotent Stem Cells by a Synergistic Combination of Cytokines, Small Compounds, and Serum-Free Medium [ Front Cell Dev Biol, 2020, 15;8:309] PubMed: 32509776
Gastric-cancer-derived Mesenchymal Stem Cells: A Promising Target for Resveratrol in the Suppression of Gastric Cancer Metastasis [ Hum Cell, 2020, 29] PubMed: 32350750
Hyperin Controls the Development and Therapy of Gastric Cancer via Regulating Wnt/β-Catenin Signaling [ Cancer Manag Res, 2020, 12:11773-11782] PubMed: 33235505
Activation of Wnt/β-catenin Pathway Causes Insulin Resistance and Increases Lipogenesis in HepG2 Cells via Regulation of Endoplasmic Reticulum Stress [ Biochem Biophys Res Commun, 2020, 4;526(3):764-771] PubMed: 32265032
lncRNA-ATB Promotes Stemness Maintenance in Colorectal Cancer by Regulating Transcriptional Activity of the β-Catenin Pathway [ Exp Ther Med, 2020, 19(4):3097-3103] PubMed: 32256798
Robust differentiation of human pluripotent stem cells into endothelial cells via temporal modulation of ETV2 with modified mRNA [ Sci Adv, 2020, 6(30):eaba7606] PubMed: 32832668

RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.

SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.