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Formula | C27H40N8O7 |
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Molecular Weight | 588.66 | CAS No. | 188968-51-6 | |
Solubility (25°C)* | In vitro | DMSO | 100 mg/mL (169.87 mM) | |
Water | 100 mg/mL (169.87 mM) | |||
Ethanol | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
Description | Cilengitide (EMD 121974, EMD-12192, EMD-85189, NSC-707544) is a potent and selective inhibitor of the integrins ανβ3 and ανβ5 with IC50 of 4 and 79 nM, respectively. | ||||
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Targets |
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In vitro | Cilengitide inhibits a receptor reported to activate KRAS named ITGAV. [2] |
Cell Assay: |
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Animal Study: |
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hUC-MSCs-derived MFGE8 ameliorates locomotor dysfunction via inhibition of ITGB3/ NF-κB signaling in an NMO mouse model [ NPJ Regen Med, 2024, 9(1):4] | PubMed: 38242900 |
Milk fat globule epidermal growth factor 8 alleviates liver injury in severe acute pancreatitis by restoring autophagy flux and inhibiting ferroptosis in hepatocytes [ World J Gastroenterol, 2024, 30(7):728-741] | PubMed: 38515944 |
Tissue factor is a critical regulator of radiation therapy-induced glioblastoma remodeling [ Cancer Cell, 2023, 41(8):1480-1497.e9] | PubMed: 37451272 |
Self-generated gradients steer collective migration on viscoelastic collagen networks [ Nat Mater, 2022, 10.1038/s41563-022-01259-5] | PubMed: 35637338 |
Developmental endothelial locus-1 protects from hypertension-induced cardiovascular remodeling via immunomodulation [ J Clin Invest, 2022, e126155] | PubMed: 35133978 |
Integrin β3-PKM2 pathway-mediated aerobic glycolysis contributes to mechanical ventilation-induced pulmonary fibrosis [ Theranostics, 2022, 12(14):6057-6068] | PubMed: 36168620 |
Fibroblast growth factor receptor 4 promotes glioblastoma progression: a central role of integrin-mediated cell invasiveness [ Acta Neuropathol Commun, 2022, 10(1):65] | PubMed: 35484633 |
Macrophage-like THP-1 Cells Derived from High-Density Cell Culture Are Resistant to TRAIL-Induced Cell Death via Down-Regulation of Death-Receptors DR4 and DR5 [ Biomolecules, 2022, 12(2)150] | PubMed: 35204655 |
Cell clusters adopt a collective amoeboid mode of migration in confined nonadhesive environments [ Sci Adv, 2022, 8(39):eabp8416] | PubMed: 36179021 |
Cellular mechanisms of cancer collective invasion and response to treatments [ HAL open science, 2022, version 1 (17-06-2023)] | PubMed: none |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.