CID44216842

Catalog No.S6000 Batch:S600001

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Technical Data

Formula

C22H20BrN3O3S

Molecular Weight 486.38 CAS No. 1222513-26-9
Solubility (25°C)* In vitro DMSO 97 mg/mL (199.43 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description CID44216842 (Cdc42-IN-1) is a potent Cdc42-selective guanine nucleotide binding lead inhibitor with EC50s of 1.0 μM and 1.2 μM for Cdc42WT and Cdc42Q61L mutant in GTP binding assay, respectively.
Targets
Cdc42 WT [1]
(in GTP binding assay)
Cdc42 Q61L [1]
(in GTP binding assay)
1.0 μM(EC50) 1.2 μM

Protocol (from reference)

Selleck's CID44216842 has been cited by 2 publications

Proton pump inhibitors enhance macropinocytosis-mediated extracellular vesicle endocytosis by inducing membrane v-ATPase assembly [ J Extracell Vesicles, 2024, 13(4):e12426] PubMed: 38532609
Activation of the mevalonate pathway in response to anti-cancer treatments drives glioblastoma recurrences through activation of Rac-1 [ bioRxiv, 2023, 2023.07.23.550205] PubMed: 37546917

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.