CID 2011756

Catalog No.S5792 Batch:S579202

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Technical Data

Formula

C22H21ClN2O3
Molecular Weight 396.87 CAS No. 638156-11-3
Solubility (25°C)* In vitro DMSO 30 mg/mL (75.59 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description CID 2011756 is an inhibitor of protein kinase D (PKD) with IC50 values of 3.2, 0.6, and 0.7 μM for PKD1, PKD2, and PKD3, respectively.
Targets
PKD2 [1] PKD3 [1] PKD1 [1]
0.6 μM 0.7 μM 3.2 μM

Protocol (from reference)

Cell Assay:

[1]
  • Cell lines

    LNCaP cells

  • Concentrations

    50 µM

  • Incubation Time

    45 min

  • Method

    LNCaP cells were pretreated with a single concentration (i.e., 50 µM) of test compound for 45 min, followed by PMA stimulation at 10 nM for 20 min. Whole cell lysates were immunoblotted for phosphorylated Ser916-PKD1 with GAPDH serving as a loading control.

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.