Chlorzoxazone

Catalog No.S4155 Batch:S415501

Technical Data

Formula	C₇H₄ClNO₂
Molecular Weight	169.57	CAS No.	95-25-0
Solubility (25°C)*	In vitro	DMSO	34 mg/mL (200.5 mM)
		Ethanol	34 mg/mL (200.5 mM)
		Water	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description	Chlorzoxazone(Chlorzoxazon,Paraflex) is a muscle-relaxing drug,and a probe for human liver cytochrome P-450IIE1.
In vitro	Chlorzoxazone is well documented to be metabolized mainly to 6-hydroxychlorzoxazone physically, which is catalyzed primarily by CYP2E1. Other human hepatic P450 enzymes, namely CYP1A1, CYP1A2 and CYP3A4 may also contribute to Chlorzoxazone metabolism. Chlorzoxazone has been used as a probe for CYP2E1 activity in microsomes from various sources (e.g., liver, kidney, lung cells) as well as directly in cell cultures. ^[1] Chlorzoxazone is a centrally acting skeletal muscle relaxant, which acts on the spinal cord by depressing reflexes. Chlorzoxazone is able to activate rat brain SK2 channel currents in cells. The maximal response to Chlorzoxazone is achieved at 1 mM, which is 44% ( 62%) of the response to 1 mM 1-EBIO. ^[2]

Description

Chlorzoxazone(Chlorzoxazon,Paraflex) is a muscle-relaxing drug,and a probe for human liver cytochrome P-450IIE1.

In vitro

Chlorzoxazone is well documented to be metabolized mainly to 6-hydroxychlorzoxazone physically, which is catalyzed primarily by CYP2E1. Other human hepatic P450 enzymes, namely CYP1A1, CYP1A2 and CYP3A4 may also contribute to Chlorzoxazone metabolism. Chlorzoxazone has been used as a probe for CYP2E1 activity in microsomes from various sources (e.g., liver, kidney, lung cells) as well as directly in cell cultures. ^[1] Chlorzoxazone is a centrally acting skeletal muscle relaxant, which acts on the spinal cord by depressing reflexes. Chlorzoxazone is able to activate rat brain SK2 channel currents in cells. The maximal response to Chlorzoxazone is achieved at 1 mM, which is 44% ( 62%) of the response to 1 mM 1-EBIO. ^[2]

Protocol (from reference)

References

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

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