Cepharanthine

Catalog No.S4238 Batch:S423802

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Technical Data

Formula

C37H38N2O6
Molecular Weight 606.71 CAS No. 481-49-2
Solubility (25°C)* In vitro DMSO 100 mg/mL (164.82 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description Cepharanthine (NSC-623442) is a biscoclaurine alkaloid inhibiting tumor necrosis factor (TNF)-α-mediated NFκB stimulation, plasma membrane lipid peroxidation and platelet aggregation and suppressing cytokine production.
In vitro Treatment of SaOS2 cells with Cepharanthine (CEP) (2.5-20 μmol/L) inhibits the cell growth in a concentration- and time-dependent manner. CEP (10 μmol/L) caused cell cycle arrest at G(1) phase and induced apoptosis of SaOS2 cells. CEP (10 and 15 μmol/L) significantly decreases the expression of STAT3 in SaOS2 cells. Furthermore, CEP (5 and 10 μmol/L) significantly inhibits the expression of target genes of STAT3, including the anti-apoptotic gene Bcl-xL and the cell cycle regulators c-Myc and cyclin D1.
In vivo In nude mouse xenografts of SaOS2 cells, Cepharanthine (CEP) (20 mg•kg(-1)•d(-1), ip for 19 d) significantly reduces the volume and weight of the tumor.

Protocol (from reference)

Selleck's Cepharanthine has been cited by 7 publications

Activity and inhibition of the SARS-CoV-2 Omicron nsp13 R392C variant using RNA duplex unwinding assays [ SLAS Discov, 2024, S2472-5552(24)00007-8] PubMed: 38301954
Identification of a group of bisbenzylisoquinoline (BBIQ) compounds as ferroptosis inhibitors [ Cell Death Dis, 2022, 13(11):1000] PubMed: 36435804
Disturbing effect of cepharanthine on valve interstitial cells calcification via regulating glycolytic metabolism pathways [ Front Pharmacol, 2022, 13:1070922] PubMed: 36467082
Network analysis-based strategy to investigate the protective effect of cepharanthine on rat acute respiratory distress syndrome [ Front Pharmacol, 2022, 13:1054339] PubMed: 36386130
Cepharanthine inhibits hepatocellular carcinoma cell growth and proliferation by regulating amino acid metabolism and suppresses tumorigenesis in vivo [ Int J Biol Sci, 2021, 17(15):4340-4352] PubMed: 34803502
Cepharanthine ameliorates titanium particle-induced osteolysis by inhibiting osteoclastogenesis and modulating OPG/RANKL ratio in a murine model. [ Biochem Biophys Res Commun, 2019, 517(3):407-412] PubMed: 31376931
Cepharanthine Prevents Estrogen Deficiency-Induced Bone Loss by Inhibiting Bone Resorption [ Front Pharmacol, 2018, 9:210] PubMed: 29636680

RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.