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Formula | C18H13ClF6N2O3 |
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Molecular Weight | 454.75 | CAS No. | 285986-88-1 | |
Solubility (25°C)* | In vitro | DMSO | 90 mg/mL (197.91 mM) | |
Ethanol | 4 mg/mL (8.79 mM) | |||
Water | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
Description | CCG-1423 is a specific RhoA pathway inhibitor, which inhibits SRF-mediated transcription. | |
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Targets |
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In vitro | CCG-1423 selectively inhibits SRF-mediated transcription activated by Rho pathway signaling, and specifically inhibits LPA-stimulated DNA synthesis. CCG-1423 also selectively inhibits the proliferation of RhoC-overexpressing melanoma cells (A375M2 and SK-Mel-147), and strongly suppresses the Rho-dependent invasion by PC-3 cells. [1] CCG-1423 in combination with LY294002 enhances differentiation of mouse embryonic stem cells into intermediate mesoderm through BMP7-positive cells. [2] In H9c2 cells, CCG-1423 inhibits MRTF nuclear localization, and completely blocks STARS proximal reporter activity. [3] CCG-1423, as a Rho/MRTF/SRF pathway inhibitor, also represses both matrix-stiffness and TGF-beta-induced fibrogenesis in human colonic myofibroblasts. [4] |
Cell Assay:[1] |
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Data from [Data independently produced by , , Cell Signal, 2017, 31:87-95]
Data from [Data independently produced by , , Cellular Signalling, 2017, 31:87-95.]
Data from [Data independently produced by , , Biomed Pharmacother, 2018, 104:718-728]
Data from [Data independently produced by , , Oncol Rep, 2018, 39(2):465-472]
IQGAP1 and NWASP promote human cancer cell dissemination and metastasis by regulating β1-integrin via FAK and MRTF/SRF [ Cell Rep, 2024, 43(4):113989] | PubMed: 38536816 |
3D printed pore morphology mediates bone marrow stem cell behaviors via RhoA/ROCK2 signaling pathway for accelerating bone regeneration [ Bioact Mater, 2023, 26:413-424] | PubMed: 36969106 |
The collateral activity of RfxCas13d can induce lethality in a RfxCas13d knock-in mouse model [ Genome Biol, 2023, 24(1):20] | PubMed: 36726140 |
Osteogenesis-Inducing Chemical Cues Enhance the Mechanosensitivity of Human Mesenchymal Stem Cells for Osteogenic Differentiation on a Microtopographically Patterned Surface [ Adv Sci (Weinh), 2022, e2200053] | PubMed: 35373921 |
Increased Expression of LMCD1 in Scleroderma-Associated Interstitial Lung Disease is Critical for Profibrotic Characteristics of Lung Myofibroblasts [ Arthritis Rheumatol, 2022, 10.1002/art.42344] | PubMed: 36103378 |
Exosomes derived from human umbilical cord mesenchymal stem cells reduce tendon injuries via the miR-27b-3p/ARHGAP5/RhoA signaling pathway [ Acta Biochim Biophys Sin (Shanghai), 2022, 54(2):232-242] | PubMed: 35130628 |
Lovastatin Inhibits RhoA to Suppress Canonical Wnt/β-Catenin Signaling and Alternative Wnt-YAP/TAZ Signaling in Colon Cancer [ Cell Transplant, 2022, 31:9636897221075749] | PubMed: 35168393 |
Phosphorylation of MICAL2 by ARG promotes head and neck cancer tumorigenesis by regulating skeletal rearrangement [ Oncogene, 2021, 10.1038/s41388-021-02101-z] | PubMed: 34750518 |
RhoA enhances osteosarcoma resistance to MPPa-PDT via the Hippo/YAP signaling pathway [ Cell Biosci, 2021, 11(1):179] | PubMed: 34627383 |
The Jumonji Domain-Containing Histone Demethylase Homolog 1D/lysine Demethylase 7A (JHDM1D/KDM7A) Is an Epigenetic Activator of RHOJ Transcription in Breast Cancer Cells [ Front Cell Dev Biol, 2021, 9:664375] | PubMed: 34249916 |
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