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Technical Data
| Formula | C20H24ClN5O2 |
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| Molecular Weight | 401.89 | CAS No. | 225120-65-0 | |
| Solubility (25°C)* | In vitro | DMSO | 80 mg/mL (199.05 mM) | |
| Ethanol | 50 mg/mL (124.41 mM) | |||
| Water | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Preparing Stock Solutions
Biological Activity
| Description | Cathepsin Inhibitor 1 is an inhibitor of Cathepsin (L, L2, S, K, B) with pIC50 of 7.9, 6.7, 6.0, 5.5 and 5.2, respectively. | ||||||||||
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| Targets |
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| In vitro | Cathepsin Inhibitor 1 (compound 25) is an inhibitor of Cathepsin (L, L2, S, K, B) with pIC50 of 7.9, 6.7, 6.0, 5.5 and 5.2, respectively. |
Protocol (from reference)
Selleck's Cathepsin Inhibitor 1 has been cited by 6 publications
| Stromal softness confines pancreatic cancer growth through lysosomal-cathepsin mediated YAP1 degradation [ Cell Mol Life Sci, 2024, 81(1):442] | PubMed: 39460766 |
| Endo-lysosomal assembly variations among human leukocyte antigen class I (HLA class I) allotypes [ Elife, 2023, 12e79144] | PubMed: 36722462 |
| Paracaspase MALT1 regulates glioma cell survival by controlling endo-lysosome homeostasis. [ EMBO J, 2020, 39(1):e102030] | PubMed: 31774199 |
| Internalization of HMGB1 (High Mobility Group Box 1) Promotes Angiogenesis in Endothelial Cells [ Arterioscler Thromb Vasc Biol, 2020, ATVBAHA120315151] | PubMed: 32998518 |
| Pannexin-1 Channels govern the Generation of Necroptotic small Extracellular Vesicles [ bioRxiv, 2019, 10.1101/537753] | PubMed: None |
| Cytosolic calcium mediates RIP1/RIP3 complex-dependent necroptosis through JNK activation and mitochondrial ROS production in human colon cancer cells [ Free Radic Biol Med, 2017, 108:433-444] | PubMed: 28414098 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.