(+)-Catechin

Catalog No.S4722 Batch:S472201

Technical Data

Formula	C₁₅H₁₄O₆
Molecular Weight	290.27	CAS No.	154-23-4
Solubility (25°C)*	In vitro	DMSO	58 mg/mL (199.81 mM)
		Ethanol	58 mg/mL (199.81 mM)
		Water	1.8 mg/mL (6.2 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description

(+)-Catechin (Cianidanol, Catechinic acid, Catechuic acid) is an antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms.,

Targets

COX-1 ^[3] (Cell-based assay)	COX-2 ^[3] (Cell-based assay)
80 μM	130 μM

In vitro

The catechin flavonoid reduces proliferation and induces apoptosis of murine lymphoma cells LB02 through modulation of antiapoptotic proteins^[1]. Treatment of human prostate cancer cells with catechin induces apoptosis and results in effects on a variety of survival signals suggesting the potential of these compounds as chemopreventive agents for prostate cancer^[2]. Catechin is well known to inhibit cyclooxygenase activity with reported IC50 values ranging from 4O μM to 943 μM. It has also been reported to act as an inhibitor of COX-1 and COX-2 with IC50 of about 80 µM and 130 μM^[3].

In vivo

Dietary catechin significantly delayed tumor onset^[5]. Continued intake of catechin, a potential antioxidant, prevents memory regression and DNA oxidative damage in senescence-accelerated (SAMP10) mice. It does not prolong the lifetime of SAMP10 mice, but it does delay brain senescence^[6]. (+)-Catechin inhibits intestinal tumor formation and suppresses Focal adhesion kinase activation in the Min/+ Mouse^[7].

Protocol (from reference)

Cell Assay:^{^[1]}	Cell lines LB02 tumor cell line Concentrations 10, 50, 100 or 200 μg/mL Incubation Time 48 h Method LB02 cells were resuspended in RPMI 10% FBS in a concentration of 5x10⁵cells/mL. The cultures were performed in 96-well round-bottomed microtitre plates in presence of different concentrations of catechin or rutin (10, 50, 100 or 200 μg/mL). After 48 h at 37 ºC in a humidified atmosphere with 5% CO2 in the air, cultures were pulsed with 1 μCi of 3H-thymidine/well and maintained for an additional 18 h period prior to a semiautomatic method harvest.
Animal Study:^{^[4]}	Animal Models Kunming mice Dosages 1, 2, 3 mg/kg Administration stomach perfusion

Cell Assay:^{^[1]}

Cell lines
LB02 tumor cell line
Concentrations
10, 50, 100 or 200 μg/mL
Incubation Time
48 h
Method
LB02 cells were resuspended in RPMI 10% FBS in a concentration of 5x10⁵cells/mL. The cultures were performed in 96-well round-bottomed microtitre plates in presence of different concentrations of catechin or rutin (10, 50, 100 or 200 μg/mL). After 48 h at 37 ºC in a humidified atmosphere with 5% CO2 in the air, cultures were pulsed with 1 μCi of 3H-thymidine/well and maintained for an additional 18 h period prior to a semiautomatic method harvest.

Animal Study:^{^[4]}

Animal Models
Kunming mice
Dosages
1, 2, 3 mg/kg
Administration
stomach perfusion

References

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Selleck's (+)-Catechin has been cited by 4 publications

Systematic pharmacology-based strategy to explore the mechanism of Semen Strychni for treatment of papillary thyroid carcinoma [ Sci Rep, 2023, 13(1):18492.]	PubMed: 37898675
Systematic pharmacology-based strategy to explore the mechanism of Semen Strychni for treatment of papillary thyroid carcinoma [ Sci Rep, 2023, 13(1):18492]	PubMed: 37898675
Systematic pharmacology-based strategy to explore the mechanism of Semen Strychni for treatment of papillary thyroid carcinoma [ Sci Rep, 2023, 10.1038/s41598-023-45741-9]	PubMed: 37898675
(-)-Epicatechin acts as a potent agonist of the membrane androgen receptor, ZIP9 (SLC39A9), to promote apoptosis of breast and prostate cancer cells [ J Steroid Biochem Mol Biol, 2021, 211:105906]	PubMed: 33989703

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

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