CASIN

Catalog No.S6875 Batch:S687501

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Technical Data

Formula

C20H22N2O
Molecular Weight 306.4 CAS No. 425399-05-9
Solubility (25°C)* In vitro DMSO 61 mg/mL (199.08 mM)
Ethanol 61 mg/mL (199.08 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description CASIN (Pirl1-related Compound 2) directly inhibits activation of Cdc42/RhoGDI with IC50 of 2 μM.
Targets
Cdc42/RhoGDI [1]
(Cell-free assay)
2 μM
In vitro

CASIN facilitates the eradication of ALL LSCs by AraC + QC and prolongs the survival of both primary and secondary recipients without affecting long-term normal human hematopoiesis.[2]
In vivo

The combination of CASIN with the AraC + QC regimen eliminates quiescent LSCs and prolongs the survival of xenografted mice.[2]

Protocol (from reference)

Cell Assay:

[2]
  • Cell lines

    Human ALL cell line Molt4-Luc2 expressing luciferase maker

  • Concentrations

    5 μM

  • Incubation Time

    --

  • Method

    For in vitro studies, CASIN (containing 0.02-0.2% DMSO) was used at 5 μM in the culture medium.
Animal Study:

[2]
  • Animal Models

    Humanized NSGS mice expressing transgenic cDNA encoding human SCF, GM-SCF, and IL-3 (NOD SCID IL-2Rγ -/- SCF, GM-CSF, and IL-3) 36

  • Dosages

    2.4 mg/kg

  • Administration

    i.p.

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

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