Carbazochrome

Catalog No.S5084 Batch:S508401

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Technical Data

Formula

C10H12N4O3
 
Molecular Weight 236.23 CAS No. 69-81-8
Solubility (25°C)* In vitro DMSO 33 mg/mL (139.69 mM)
 
 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Carbazochrome (Adedolon, Adchnon, Adrenostazin, Cromadrenal, Adona, AC-17) is a hemostatic agent that causes the aggregation and adhesion of platelets in the blood to form a platelet plug, ceasing blood flow from an open wound.
In vitro AC-17 (0.1-1 M) reversed the barrier dysfunction induced by tryptase, thrombin and bradykinin without affecting the endothelial permeability enhanced by Ca2+ ionophores such as ionomycin and A23187 or phorbol 12-myristate 13-acetate. AC-17 reversed the tryptase-induced formation of actin stress fibres and disruption of VE-cadherin in porcine aortic endothelial cells (PAECs)[2].
In vivo AC-17 is a potent agent that inhibits the severe pulmonary dysfunction induced by the intravenous injection of radiographic contrast media[1].

Protocol (from reference)

Cell Assay:

[2]
  • Cell lines

    porcine aortic endothelial cells (PAECs)

  • Concentrations

    0.1, 1, 10 μM

  • Incubation Time

    30 min

  • Method

    Cells were labelled with [3H]myoinositol for 12 h. After preincubation with 10 mM LiCl, cells were stimulated with 1 µM bradykinin or 10 nM thrombin. AC-17 was included 30 min before stimulation. The [3H]IP3 formed was measured at 30 s after the stimulation.
Animal Study:

[1]
  • Animal Models

    Male Sprague-Dawley rats

  • Dosages

    10 mg/kg

  • Administration

    i.v.

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.