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Technical Data
| Formula | C11H7IN2O4 |
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| Molecular Weight | 358.09 | CAS No. | 314054-00-7 | |
| Solubility (25°C)* | In vitro | DMSO | 72 mg/mL (201.06 mM) | |
| Ethanol | 4 mg/mL (11.17 mM) | |||
| Water | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | STING inhibitor C-176 is a potent, small-molecule inhibitor of STING, a central signaling component of the intracellular DNA sensing pathway. | |
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| In vitro | C-176 strongly reduces STING-mediated, but not RIG-I- or TBK1-mediated, IFNβ reporter activity. It directly targets mouse STING (mmSTING) but not human STING (hsSTING)[1]. |
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| In vivo | C-176 attenuates STING-associated autoinflammatory disease in mice[1]. |
Protocol (from reference)
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References
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Selleck's C-176 has been cited by 35 publications
| MRE11 liberates cGAS from nucleosome sequestration during tumorigenesis [ Nature, 2024, 625(7995):585-592] | PubMed: 38200309 |
| STING orchestrates the neuronal inflammatory stress response in multiple sclerosis [ Cell, 2024, 187(15):4043-4060.e30] | PubMed: 38878778 |
| Mitochondrial DNA-boosted dendritic cell-based nanovaccination triggers antitumor immunity in lung and pancreatic cancers [ Cell Rep Med, 2024, 5(7):101648] | PubMed: 38986624 |
| Up-regulation of HSP90α in HDM-induced asthma causes pyroptosis of airway epithelial cells by activating the cGAS-STING-ER stress pathway [ Int Immunopharmacol, 2024, 131:111917] | PubMed: 38527402 |
| Carbon ion irradiation exerts antitumor activity by inducing cGAS-STING activation and immune response in prostate cancer-bearing mice [ Cancer Med, 2024, 13(2):e6950] | PubMed: 38379323 |
| Knockdown of S100A2 inhibits the aggressiveness of endometrial cancer by activating STING pathway [ J Obstet Gynaecol, 2024, 44(1):2361849] | PubMed: 38920019 |
| The cGAS-STING pathway-dependent sensing of mitochondrial DNA mediates ocular surface inflammation [ Signal Transduct Target Ther, 2023, 8(1):371] | PubMed: 37735446 |
| GPR162 activates STING dependent DNA damage pathway as a novel tumor suppressor and radiation sensitizer [ Signal Transduct Target Ther, 2023, 8(1):48] | PubMed: 36725837 |
| The cGAS-STING pathway-dependent sensing of mitochondrial DNA mediates ocular surface inflammation [ Signal Transduct Target Ther, 2023, 8(1):371] | PubMed: 37735446 |
| RING finger protein 13 protects against nonalcoholic steatohepatitis by targeting STING-relayed signaling pathways [ Nat Commun, 2023, 14(1):6635] | PubMed: 37857628 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.