C-176

Catalog No.S6575 Batch:S657503

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Technical Data

Formula

C11H7IN2O4
Molecular Weight 358.09 CAS No. 314054-00-7
Solubility (25°C)* In vitro DMSO 72 mg/mL (201.06 mM)
Ethanol 1.5 mg/mL (4.18 mM)
Water Insoluble
In vivo (Add solvents to the product individually and in order)
Clear solution
5%DMSO 40%PEG300 5%Tween80 50%ddH2O
0.895mg/ml Taking the 1 mL working solution as an example, add 50 μL of 17.9 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results. 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description STING inhibitor C-176 is a potent, small-molecule inhibitor of STING, a central signaling component of the intracellular DNA sensing pathway.
Targets
STING [1]
In vitro

C-176 strongly reduces STING-mediated, but not RIG-I- or TBK1-mediated, IFNβ reporter activity. It directly targets mouse STING (mmSTING) but not human STING (hsSTING)[1].
In vivo

C-176 attenuates STING-associated autoinflammatory disease in mice[1].

Protocol (from reference)

Cell Assay:

[2]
  • Cell lines

    H526 cells

  • Concentrations

    1 μM

  • Incubation Time

    48 h

  • Method

    Cells were treated 1 μM C176 and 1 μM AZD1775 for 48 h
Animal Study:

[1]
  • Animal Models

    C57BL/6J mice

  • Dosages

    750 nmol/200 μL

  • Administration

    ip

Selleck's C-176 has been cited by 35 publications

MRE11 liberates cGAS from nucleosome sequestration during tumorigenesis [ Nature, 2024, 625(7995):585-592] PubMed: 38200309
STING orchestrates the neuronal inflammatory stress response in multiple sclerosis [ Cell, 2024, 187(15):4043-4060.e30] PubMed: 38878778
Mitochondrial DNA-boosted dendritic cell-based nanovaccination triggers antitumor immunity in lung and pancreatic cancers [ Cell Rep Med, 2024, 5(7):101648] PubMed: 38986624
Up-regulation of HSP90α in HDM-induced asthma causes pyroptosis of airway epithelial cells by activating the cGAS-STING-ER stress pathway [ Int Immunopharmacol, 2024, 131:111917] PubMed: 38527402
Carbon ion irradiation exerts antitumor activity by inducing cGAS-STING activation and immune response in prostate cancer-bearing mice [ Cancer Med, 2024, 13(2):e6950] PubMed: 38379323
Knockdown of S100A2 inhibits the aggressiveness of endometrial cancer by activating STING pathway [ J Obstet Gynaecol, 2024, 44(1):2361849] PubMed: 38920019
The cGAS-STING pathway-dependent sensing of mitochondrial DNA mediates ocular surface inflammation [ Signal Transduct Target Ther, 2023, 8(1):371] PubMed: 37735446
GPR162 activates STING dependent DNA damage pathway as a novel tumor suppressor and radiation sensitizer [ Signal Transduct Target Ther, 2023, 8(1):48] PubMed: 36725837
The cGAS-STING pathway-dependent sensing of mitochondrial DNA mediates ocular surface inflammation [ Signal Transduct Target Ther, 2023, 8(1):371] PubMed: 37735446
RING finger protein 13 protects against nonalcoholic steatohepatitis by targeting STING-relayed signaling pathways [ Nat Commun, 2023, 14(1):6635] PubMed: 37857628

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.