Bulevirtide (Myrcludex B)

Catalog No.P1105 Batch:P110501

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Technical Data

Formula

C248H355N65O72
Molecular Weight 5398.86 CAS No. 2012558-47-1
Solubility (25°C)* In vitro Water 25 mg/mL (4.63 mM)
 
 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Bulevirtide (Myrcludex B) is a sodium-taurocholate co-transporting polypeptide (NTCP) receptor inhibitor with IC50 of ∼80 pM and inactivates NTCP function at concentrations far below those required to block bile salt transport.
Targets
NTCP [1]
∼80 pM
In vitro

Bulevirtide (Myrcludex B) is a sodium-taurocholate co-transporting polypeptide (NTCP) receptor inhibitor with IC50 of ∼80 pM and inactivates NTCP function at concentrations far below those required to block bile salt. transport.
Density 95.0~105.0%

Protocol (from reference)

Cell Assay:

[2]
  • Cell lines

    U2OS cells

  • Concentrations

    200 nM

  • Incubation Time

    1 h

  • Method

    Cells were treated with indicated concentration of drug for 1 h.
Animal Study:

[2]
  • Animal Models

    Male OATP1a/1b-deficient mice

  • Dosages

    2.5 mg/kg

  • Administration

    s.c.

Selleck's Bulevirtide (Myrcludex B) has been cited by 1 publication

High-Throughput Screening of Antiviral Compounds Using a Recombinant Hepatitis B Virus and Identification of a Possible Infection Inhibitor, Skimmianine [ Viruses, 2024, 16(8)1346] PubMed: 39205320

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.