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Technical Data
| Formula | C12H17NO3 |
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| Molecular Weight | 223.27 | CAS No. | 2438-72-4 | |
| Solubility (25°C)* | In vitro | DMSO | 45 mg/mL (201.54 mM) | |
| Ethanol | 3 mg/mL (13.43 mM) | |||
| Water | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Bufexamac(Bufexamic acid) is a COX inhibitor for IFN-α release with EC50 of 8.9 μM. | ||
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| Targets |
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| In vitro | Bufexamac is a specific inhibitor of class IIB histone deacetylases (HDAC6 and HDAC10). Treatment of peripheral blood mononuclear cells with bufexamac inhibits the secretion of IFN-α. [1] Bufexamac is a frequent and relevant contact sensitizer. Bufexamac is a non-steroidal anti-inflammatory drug. [2] |
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| Features | A specific inhibitor of class IIB histone deacetylases. |
Protocol (from reference)
References
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Customer Product Validation
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, , Nat Biotechnol, 2015, 33(4):415-23.
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Data from [Data independently produced by , , Oncotarget, 2016, 7(37):59388-59401]
Selleck's Bufexamac has been cited by 6 publications
| In-Cell Testing of Zinc-Dependent Histone Deacetylase Inhibitors in the Presence of Class-Selective Fluorogenic Substrates: Potential and Limitations of the Method [ Biomedicines, 2024, 12(6)1203] | PubMed: 38927410 |
| Pre-Senescence Induction in Hepatoma Cells Favors Hepatitis C Virus Replication and Can Be Used in Exploring Antiviral Potential of Histone Deacetylase Inhibitors [ Int J Mol Sci, 2021, 22(9)4559] | PubMed: 33925399 |
| HDAC6 Is Involved in the Histone Deacetylation of In Vitro Maturation Oocytes and the Reprogramming of Nuclear Transplantation in Pig [ Reprod Sci, 2021, 10.1007/s43032-021-00533-2] | PubMed: 33725312 |
| Absence of autophagy promotes apoptosis by modulating the ROS-dependent RLR signaling pathway in classical swine fever virus-infected cells. [ Autophagy, 2016, 12(10):1738-1758] | PubMed: 27463126 |
| HDAC10 promotes lung cancer proliferation via AKT phosphorylation. [Yang Y, et al. Oncotarget, 2016, 7(37):59388-59401] | PubMed: 27449083 |
| Acetylation site specificities of lysine deacetylase inhibitors in human cells. [Scholz C, et al. Nat Biotechnol, 2015, 10.1038/nbt.3130] | PubMed: 25751058 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.