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Technical Data
| Formula | C19H12ClNO6S |
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| Molecular Weight | 417.82 | CAS No. | 219793-45-0 | |
| Solubility (25°C)* | In vitro | DMSO | 84 mg/mL (201.04 mM) | |
| Water | Insoluble | |||
| Ethanol | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | BTB06584 is an IF1-dependent, selective inhibitor of the mitochondrial F1 Fo-ATPase. | |
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| In vitro | BTB06584 IF1-dependently inhibits F1 Fo-ATPase activity with no effect on without compromising ATP synthesis, and also limits ischemia-induced injury caused by reversal of the mitochondrial F1 Fo-ATP synthase. [1] | |
| In vivo | BTB06584 rescues the defective haemoglobin synthesis in zebrafish pinotage (pnt) mutants without causing significant toxicity. [1] |
Protocol (from reference)
Customer Product Validation
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Data from [Data independently produced by , , Oncotarget, 2017, doi: 10.18632/oncotarget.18657]
Selleck's BTB06584 has been cited by 3 publications
| Enzymatic Redox Properties and Cytotoxicity of Irreversible Nitroaromatic Thioredoxin Reductase Inhibitors in Mammalian Cells [ Int J Mol Sci, 2023, 24(15)12460] | PubMed: 37569833 |
| Early embryonic exposure of ionizing radiations disrupts zebrafish pigmentation [Wang Y, et al. J Cell Physiol, 2018, 234(1):940-949] | PubMed: 30144054 |
| Selective ATP hydrolysis inhibition in F1Fo ATP synthase enhances radiosensitivity in non-small-cell lung cancer cells (A549) [ Oncotarget, 2017, 8(32):53602-53612] | PubMed: 28881834 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.