Brusatol

Catalog No.S7956 Batch:S795602

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Technical Data

Formula

C26H32O11
Molecular Weight 520.53 CAS No. 14907-98-3
Solubility (25°C)* In vitro DMSO 100 mg/mL (192.11 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description Brusatol (NSC 172924), isolated from the fruit of B. javanica, is a NRF2 inhibitor.
Targets
Nrf2 [1]
In vitro

Brusatol provokes a rapid and transient depletion of Nrf2 protein, through a posttranscriptional mechanism, in mouse Hepa-1c1c7 hepatoma cells and freshly isolated primary human hepatocytes [1].
In vivo

Brusatol inhibits Nrf2 signaling, reduces tumor burden, and ameliorates chemoresistance in both in vitro and in vivo cancer models[1].

Protocol (from reference)

Selleck's Brusatol has been cited by 19 publications

Meningioma achieves malignancy and erastin-induced ferroptosis resistance through FOXM1-AURKA-NRF2 axis [ Redox Biol, 2024, 72:103137] PubMed: 38642502
Sulforaphane Regulates Macrophage M1/M2 Polarization to Attenuate Macrophage-induced Caco-2 Cell Injury in an Inflammatory Environment [ Iran J Immunol, 2024, 21(1)] PubMed: 38314669
LRRK2 kinase activity restricts NRF2-dependent mitochondrial protection in microglia [ bioRxiv, 2024, 2024.07.09.602769] PubMed: 39026883
DDRGK1 Enhances Osteosarcoma Chemoresistance via Inhibiting KEAP1-Mediated NRF2 Ubiquitination [ Adv Sci (Weinh), 2023, 10(14):e2204438] PubMed: 36965071
Celastrol targeting Nedd4 reduces Nrf2-mediated oxidative stress in astrocytes after ischemic stroke [ J Pharm Anal, 2023, 13(2):156-169] PubMed: 36908855
Celastrol targeting Nedd4 reduces Nrf2-mediated oxidative stress in astrocytes after ischemic stroke [ J Pharm Anal, 2023, 13(2):156-169] PubMed: 36908855
Dihydroartemisinin-induced ferroptosis in acute myeloid leukemia: links to iron metabolism and metallothionein [ Cell Death Discov, 2023, 9(1):97] PubMed: 36928207
Withaferin A Increases the Effectiveness of Immune Checkpoint Blocker for the Treatment of Non-Small Cell Lung Cancer [ Cancers (Basel), 2023, 15(12)3089] PubMed: 37370701
Dissecting molecular mechanisms underlying ferroptosis in human umbilical cord mesenchymal stem cells: Role of cystathionine γ-lyase/hydrogen sulfide pathway [ World J Stem Cells, 2023, 15(11):1017-1034] PubMed: 38058959
Targeting SELPLG/P-selectin glycoprotein ligand 1 in preclinical ARDS: Genetic and epigenetic regulation of the SELPLG promoter [ Pulm Circ, 2023, 13(1):e12206] PubMed: 36873461

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

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