BRM/BRG1 ATP Inhibitor-1

Catalog No.E0111 Batch:E011102

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Technical Data

Formula

C11H9F3N4O2S
Molecular Weight 318.27 CAS No. 2270879-17-7
Solubility (25°C)* In vitro DMSO 64 mg/mL (201.08 mM)
Ethanol 9 mg/mL (28.27 mM)
Water Insoluble
In vivo (Add solvents to the product individually and in order)
Clear solution
5%DMSO 40%PEG300 5%Tween80 50%ddH2O
3.2mg/ml Taking the 1 mL working solution as an example, add 50 μL 64 mg/ml clarified DMSO stock solution to 400 μL PEG300, mix evenly to clarify it; add 50 μL Tween80 to the above system, mix evenly to clarify it; then continue to add 500 μL ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results. 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description BRM/BRG1 ATP Inhibitor-1 (Compound 14) is an orally active inhibitors of Brahma Homolog (BRM)/SMARCA2 (BRG1) with IC50s below 0.005 µM.
Targets
BRM [1] SMARCA2 [1]
In vitro

BRM/BRG1 ATP Inhibitor-1 (Compound 14) is an orally active inhibitors of Brahma Homolog (BRM)/SMARCA2 (BRG1) with IC50s below 0.005 µM.

Protocol (from reference)

Selleck's BRM/BRG1 ATP Inhibitor-1 has been cited by 2 publications

Stimulation of natural killer cells with small molecule inhibitors of CD38 for the treatment of neuroblastoma [ Chem Sci, 2023, 14(8):2168-2182] PubMed: 36845935
Stimulation of natural killer cells with small molecule inhibitors of CD38 for the treatment of neuroblastoma [ Chem Sci, 2023, 14(8):2168-2182] PubMed: 36845935

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.