Box5

Catalog No.P1216 Batch:P121601

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Technical Data

Formula

C25H42N6O11S2

Molecular Weight 666.76 CAS No. 881188-48-3
Solubility (25°C)* In vitro DMSO 100 mg/mL (149.97 mM)
Ethanol 100 mg/mL (149.97 mM)
Water 2 mg/mL (2.99 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Box5, a Wnt5a-derived N-butyloxycarbonyl hexapeptide (t-Boc-Met-Asp-Gly-Cys-Glu-Leu), acts as an Wnt5a antagonist, inhibits the basal migration and invasion of Wnt5a-expressing HTB63 melanoma cells, antagonizes the effects of Wnt5a on melanoma cell migration and invasion by directly inhibiting Wnt5a-induced PKC and Ca(2+) signaling.
Targets
Wnt5a [1]
Density 95.0~105.0%

Protocol (from reference)

Selleck's Box5 has been cited by 2 publications

Loss of p14 diminishes immunogenicity in melanoma via non-canonical Wnt signaling by reducing the peptide surface density [ Mol Oncol, 2024, 10.1002/1878-0261.13660] PubMed: 38807304
Single-nucleus and spatial landscape of the sub-ventricular zone in human glioblastoma [ bioRxiv, 2024, 2024.04.24.590852] PubMed: 38712234

RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.

SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.