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Technical Data
| Formula | C25H42N6O11S2 |
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| Molecular Weight | 666.76 | CAS No. | 881188-48-3 | |
| Solubility (25°C)* | In vitro | DMSO | 100 mg/mL (149.97 mM) | |
| Ethanol | 100 mg/mL (149.97 mM) | |||
| Water | 2 mg/mL (2.99 mM) | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Preparing Stock Solutions
Biological Activity
| Description | Box5, a Wnt5a-derived N-butyloxycarbonyl hexapeptide (t-Boc-Met-Asp-Gly-Cys-Glu-Leu), acts as an Wnt5a antagonist, inhibits the basal migration and invasion of Wnt5a-expressing HTB63 melanoma cells, antagonizes the effects of Wnt5a on melanoma cell migration and invasion by directly inhibiting Wnt5a-induced PKC and Ca(2+) signaling. | |||||
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| Targets |
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| Density | 95.0~105.0% | |||||
Protocol (from reference)
Selleck's Box5 has been cited by 3 publications
| Regular exercise ameliorates high-fat diet-induced depressive-like behaviors by activating hippocampal neuronal autophagy and enhancing synaptic plasticity [ Cell Death Dis, 2024, 15(10):737] | PubMed: 39389946 |
| Loss of p14 diminishes immunogenicity in melanoma via non-canonical Wnt signaling by reducing the peptide surface density [ Mol Oncol, 2024, 10.1002/1878-0261.13660] | PubMed: 38807304 |
| Single-nucleus and spatial landscape of the sub-ventricular zone in human glioblastoma [ bioRxiv, 2024, 2024.04.24.590852] | PubMed: 38712234 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.