Bornyl acetate

Catalog No.S3893 Batch:S389301

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Technical Data

Formula

C12H20O2
Molecular Weight 196.29 CAS No. 76-49-3
Solubility (25°C)* In vitro  
 
 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Biological Activity

Description Bornyl acetate (Isobornyl, Bornyl acetic ether, 2-Camphanol), the main volatile constituent in numerous conifer oils and some Chinese traditional herbs, exhibits anti-inflammatory property and it is used as an analgesic.
In vitro Bornyl acetate induces dose-dependent growth inhibitory effects on human gastric cancer cells in vitro. Bornyl acetate potentiates the anticancer activity of 5-FU in human gastric cancer (SGC-7901) cells by inducing apoptosis, DNA fragmentation as well as G2/M cell cycle arrest[2].
In vivo Bornyl acetate downregulates the levels of proinflammatory cytokines in vitro and in vivo; reduces the number of total cells, neutrophils, and macrophages in BALF; attenuates the histologic alterations in the lung; decreases the wet-to-dry weight ratio in BALF; and suppresses NF-kappa-B inhibitor alpha, extracellular regulated protein kinases, c-JunN-terminal kinase, p38 mitogen-activated protein kinase activation[1].
Density 0.985 g/mL at 25 °C

Protocol (from reference)

Cell Assay:[1]
  • Cell lines

    RAW 264.7 cells.

  • Concentrations

    0-500 μg/mL

  • Incubation Time

    18 h

  • Method

    RAW 264.7 cells are cultured with bornyl acetate (0-500 μg/mL) in the absence or presence of LPS (1 mg/L) for 18 h. Cell viability is assessed by MTT reduction assays.
Animal Study:[1]
  • Animal Models

    BALB/c mice

  • Dosages

    25, 50, and 100mg/kg

  • Administration

    i.p.

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.