BMS303141

Catalog No.S0277 Batch:S027703

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Technical Data

Formula

C19H15Cl2NO4S
Molecular Weight 424.30 CAS No. 943962-47-8
Solubility (25°C)* In vitro DMSO 85 mg/mL (200.32 mM)
Water Insoluble
Ethanol Insoluble
In vivo (Add solvents to the product individually and in order)
Clear solution
5% DMSO 95% Corn oil
1.25mg/ml Taking the 1 mL working solution as an example, add 50 μL of 25 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results. 
Clear solution
5%DMSO 40%PEG300 5%Tween80 50%ddH2O
5.0mg/ml Taking the 1 mL working solution as an example, add 50 μL of 100 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results. 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description BMS-303141 is a potent, cell-permeable inhibitor of ATP-citrate lyase (ACL) with IC50 of 0.13 μM. BMS-303141 shows inhibition of total lipid syntheses with IC50 of 8 μM in HepG2 cells.
Targets
ACL [1]
(Cell-free assay)
0.13 μM
In vitro

In HepG2 cells, BMS-303141 shows inhibition of total lipid syntheses with an IC50 of 8 μM, and no cytotoxicity up to 50 lM under a cell based Alamar Blue cytotoxicity assay.[2]
In vivo

BMS-303141 lowers approximate 20-30% plasma cholesterol and triglycerides, as well as 30-50% fasting plasma glucose in high-fat fed mice.[2]

Protocol (from reference)

Cell Assay:

[2]
  • Cell lines

    HepG2 cells

  • Concentrations

    --

  • Incubation Time

    6 h

  • Method

    Inhibition of total lipid synthesis assay. HepG2 cells are incubated for 6 h after addition of the testing compound and [14C]-alanine is added for the last 4 h of incubation. Cell lipids are extracted, separated by TLC. The incorporation of [14C]-labeled in the total lipids is measured.
Animal Study:

[2]
  • Animal Models

    high-fat fed mice

  • Dosages

    10 or 100 mg/kg

  • Administration

    o.g.

Selleck's BMS303141 has been cited by 6 publications

ATP-citrate lyase controls endothelial gluco-lipogenic metabolism and vascular inflammation in sepsis-associated organ injury [ Cell Death Dis, 2023, 14(7):401] PubMed: 37414769
Snail acetylation by autophagy-derived acetyl-coenzyme A promotes invasion and metastasis of KRAS-LKB1 co-mutated lung cancer cells [ Cancer Commun (Lond), 2022, 42(8):716-749] PubMed: 35838183
Snail acetylation by autophagy-derived acetyl-coenzyme A promotes invasion and metastasis of KRAS-LKB1 co-mutated lung cancer cells [ Cancer Commun (Lond), 2022, 10.1002/cac2.12332] PubMed: 35838183
ATP citrate lyase controls hematopoietic stem cell fate and supports bone marrow regeneration [ EMBO J, 2022, e109463] PubMed: 35229328
ATP-citrate lyase inhibitor improves ectopic lipid accumulation in the kidney in a db/db mouse model [ Front Endocrinol (Lausanne), 2022, 13:914865] PubMed: 36568100
[ Cancers (Basel), 2019, ] PubMed: 31817870

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.