BMS-1166

Catalog No.S8859 Batch:S885901

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Technical Data

Formula

C36H33ClN2O7
Molecular Weight 641.11 CAS No. 1818314-88-3
Solubility (25°C)* In vitro DMSO 100 mg/mL (155.97 mM)
Ethanol 13 mg/mL (20.27 mM)
Water Insoluble
In vivo (Add solvents to the product individually and in order)
5% DMSO 95% Corn oil
1.65mg/ml
5%DMSO 40%PEG300 5%Tween80 50%ddH2O
5.0mg/ml
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description BMS-1166 is a novel and potent small molecule inhibitor of the PD-1/PD-L1 interaction with an IC50 of 1.4 nM.
Targets
PD-1/PD-L1 interaction [1]
1.4 nM
In vitro

BMS-1166 presents low toxicity towards tested cell lines and blocks the interaction of soluble PD-L1 with the cell surface-expressed PD-1. BMS-1166 alleviates the inhibitory effect of the soluble PD-L1 on the T-cell receptor-mediated activation of T-lymphocytes[2].

Protocol (from reference)

Selleck's BMS-1166 has been cited by 7 publications

PD-L1 regulates inflammatory programs of macrophages from human pluripotent stem cells [ Life Sci Alliance, 2024, 10.26508/lsa.202302461] PubMed: 37949473
Identification of membrane proteins targeted by small-molecule compounds using nanomagnetic beads [ Biomed Res, 2024, 45(5):179-186] PubMed: 39370296
Activation of STING by SAMHD1 Deficiency Promotes PANoptosis and Enhances Efficacy of PD-L1 Blockade in Diffuse Large B-cell Lymphoma [ Int J Biol Sci, 2023, 19(14):4627-4643] PubMed: 37781035
Activation of STING by SAMHD1 Deficiency Promotes PANoptosis and Enhances Efficacy of PD-L1 Blockade in Diffuse Large B-cell Lymphoma [ Int J Biol Sci, 2023, 19(14):4627-4643] PubMed: 37781035
Enhancement of anti-PD-1/PD-L1 immunotherapy for osteosarcoma using an intelligent autophagy-controlling metal organic framework [ Biomaterials, 2022, 282:121407] PubMed: 35217343
Homodimerized cytoplasmic domain of PD-L1 regulates its complex glycosylation in living cells [ Commun Biol, 2022, 5(1):887] PubMed: 36042378
Homodimerized cytoplasmic domain of PD-L1 regulates its complex glycosylation in living cells [ Commun Biol, 2022, 5-1:887] PubMed: 36042378

RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.

SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.