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Technical Data
| Formula | C18H16N2O2 |
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| Molecular Weight | 292.33 | CAS No. | 674289-55-5 | |
| Solubility (25°C)* | In vitro | DMSO | 58 mg/mL (198.4 mM) | |
| Ethanol | 5 mg/mL (17.1 mM) | |||
| Water | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Preparing Stock Solutions
Biological Activity
| Description | Blebbistatin is a selective inhibitor of non-muscle myosin II (NMII). It also potently inhibits several striated muscle myosins as well as vertebrate nonmuscle myosin IIA and IIB with IC50 values ranging from 0.5 to 5 μM. It promotes directional migration of corneal endothelial cells (CECs) and accelerates wound healing, and better preserves cell junctional integrity and barrier function. |
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Protocol (from reference)
References
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Selleck's Blebbistatin has been cited by 20 publications
| Bioelectric stimulation controls tissue shape and size [ Nat Commun, 2024, 15(1):2938] | PubMed: 38580690 |
| Bioengineered Hydrogels Recapitulate Fibroblast Heterogeneity in Cancer [ Adv Sci (Weinh), 2024, 11(20):e2307129] | PubMed: 38493497 |
| The ion channel TRPV5 regulates B-cell signaling and activation [ Front Immunol, 2024, 15:1386719] | PubMed: 38694510 |
| Stimulation of neutral lipid synthesis via viral growth factor signaling and ATP citrate lyase during vaccinia virus infection [ J Virol, 2024, 98(11):e0110324] | PubMed: 39475274 |
| Human iPSC-derived retinal organoids develop robust Alzheimer's disease neuropathology [ Front Cell Neurosci, 2024, 18:1340448] | PubMed: 38323188 |
| Suppression of non-muscle myosin II boosts T cell cytotoxicity against tumors [ Sci Adv, 2024, 10(44):eadp0631] | PubMed: 39485850 |
| The Mechanics of Tumor Cells Dictate Malignancy via Cytoskeleton-Mediated APC/Wnt/β-Catenin Signaling [ Research -Wash D C), 2023, 6:0224] | PubMed: 37746658 |
| The Mechanics of Tumor Cells Dictate Malignancy via Cytoskeleton-Mediated APC/Wnt/β-Catenin Signaling [ Research (Wash D C), 2023, 6:0224] | PubMed: 37746658 |
| CDR1as promotes arrhythmias in myocardial infarction via targeting the NAMPT-NAD+ pathway [ Biomed Pharmacother, 2023, 165:115267] | PubMed: 37542851 |
| Staphylococcal Enterotoxin C2 Mutant-Induced Antitumor Immune Response Is Controlled by CDC42/MLC2-Mediated Tumor Cell Stiffness [ Int J Mol Sci, 2023, 24(14)11796] | PubMed: 37511553 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.