Bithionol

Catalog No.S4552 Batch:S455201

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Technical Data

Formula

C12H6Cl4O2S
Molecular Weight 356.05 CAS No. 97-18-7
Solubility (25°C)* In vitro DMSO 71 mg/mL (199.41 mM)
Ethanol 22 mg/mL (61.78 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description Bithionol (Actamer) is a potent inhibitor of soluble adenylyl cyclase(sAC) with an IC50 of 4 μM and has antibacterial and anthelmintic properties along with algaecide activity.
Targets
sAC [2]
(Cell-free assay)
4.0 μM

Protocol (from reference)

Cell Assay:

[1]
  • Cell lines

    ovarian cancer cell lines

  • Concentrations

    0.178 μM-400μM

  • Incubation Time

    48h, 72h

  • Method

    Ovarian cancer cell lines (5 × 103 cells/well) were plated into 96-well flat bottom plates and incubated for overnight. Cells were treated with different concentrations of BT ranging from 0.178 μM to 400 μM and further incubated for 48 hrs or 72 hrs.

Selleck's Bithionol has been cited by 3 publications

Piezo1 induces endothelial responses to shear stress via soluble adenylyl Cyclase-IP3R2 circuit [ iScience, 2023, 10.1016/j.isci.2023.106661] PubMed: 37168565
Depletion of LAMP3 enhances PKA-mediated VASP phosphorylation to suppress invasion and metastasis in esophageal squamous cell carcinoma. [ Cancer Lett, 2020, 479:100-111] PubMed: 32200035
Autotaxin-Lysophosphatidic Acid Axis Blockade Improves Inflammation by Regulating Th17 Cell Differentiation in DSS-Induced Chronic Colitis Mice. [ Inflammation, 2019, 42(5):1530-1541] PubMed: 31102124

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.