Bisindolylmaleimide VIII (acetate)

Catalog No.E2839 Batch:E283901

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Technical Data

Formula

C24H22N4O2.C2H4O2
Molecular Weight 458.51 CAS No. 138516-31-1
Solubility (25°C)* In vitro DMSO 92 mg/mL (200.64 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Bisindolylmaleimide VIII (acetate) (Ro 31-7549 acetate) is a potent and selective protein kinase C (PKC) inhibitor with an IC50 of 158 nM for rat brain PKC, also exerting IC50s of 53, 195, 163, 213, and 175 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, PKC-ε, respectively.
Targets
PKC-α [1]
(in assay of PKC activity)		 PKC (Rat brain) [1]
(in assay of PKC activity)		 PKC-βII [1]
(in assay of PKC activity)		 PKC-ε [1]
(in assay of PKC activity)		 PKC-βI [1]
(in assay of PKC activity)		 View More
53 nM 158 nM 163 nM 175 nM 195 nM

Protocol (from reference)

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.