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Formula | C15H13N3O4S |
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Molecular Weight | 331.35 | CAS No. | 93987-29-2 | ||||
Solubility (25°C)* | In vitro | DMSO | 33 mg/mL (99.59 mM) | ||||
Water | Insoluble | ||||||
Ethanol | Insoluble | ||||||
In vivo (Add solvents to the product individually and in order) |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
Description | BI6015, a hepatocyte nuclear factor 4α (HNF4α) antagonist, induces loss of HNF4α expression and hepatic steatosis in vivo. BI6015 is cytotoxic to human hepatocellular carcinoma (HCC). |
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In vitro | BI-6015 is a hepatocyte nuclear factor 4α (HNF4α) antagonist, which represses insulin promoter activity through HNF4α antagonism.[1] |
In vivo | BI-6015 induces loss of HNF4α expression and hepatic steatosis in mice, also induces apoptosis in a human hepatocellular carcinoma mouse model.[1] |
Cell Assay: |
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Animal Study: |
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HNF4α ubiquitination mediated by Peli1 impairs FAO and accelerates pressure overload-induced myocardial hypertrophy [ Cell Death Dis, 2024, 15(2):135] | PubMed: 38346961 |
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