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Formula | C30H48O3 |
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Molecular Weight | 456.7 | CAS No. | 472-15-1 | |
Solubility (25°C)* | In vitro | DMSO | 20 mg/mL (43.79 mM) | |
Ethanol | 10 mg/mL (21.89 mM) | |||
Water | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
Description | Betulinic acid (ALS-357, Lupatic acid, Betulic acid), a pentacyclic triterpenoid from Syzigium claviflorum, is a inhibitor of HIV-1 with EC50 of 1.4 μ M. It's reported that Betulinic acid acts as a new activator of NF-κB.Phase 1/2. | ||||||
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Targets |
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In vitro | Betulinic acid shows anti-HIV activity by blocking HIV replication in H9 lymphocytes with an EC50 value of 1.4 μM and inhibiting uninfected H9 cell growth with an IC50 value of 13 μM. [1] Betulinic acid also acts as anti-melanoma agent through inhibiting aminopeptidase N activity with IC50 of 7.3 μM. [2] In addition, Betulinic acid inhibits eukaryotic topoisomerase I activity with IC50 of 5 μM and can be exploited as a strong candidate for anti-tumor drug. [3] | ||||||
In vivo | Betulinic acid inhibits prostate cancer cell and tumor (xenograft) growth in athymic nude mice bearing LNCaP cells and this is due, in part, to proteasome-dependent downregulation of Sp1, Sp3, Sp4 and several Sp-regulated genes. [4] |
Kinase Assay:[3] |
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Animal Study:[4] |
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Hepatocyte growth factor enhances the ability of dental pulp stem cells to ameliorate atherosclerosis in apolipoprotein E-knockout mice [ World J Stem Cells, 2024, 16(5):575-590] | PubMed: 38817328 |
Glaucocalyxin A delays the progression of OA by inhibiting NF-κB and MAPK signaling pathways [ J Orthop Surg Res, 2024, 19(1):188] | PubMed: 38500177 |
Graphene oxide/gallium nanoderivative as a multifunctional modulator of osteoblastogenesis and osteoclastogenesis for the synergistic therapy of implant-related bone infection [ Bioact Mater, 2023, 25:594-614] | PubMed: 37056253 |
N,N-Dimethyl-3β-hydroxycholenamide attenuates neuronal death and retinal inflammation in retinal ischemia/reperfusion injury by inhibiting Ninjurin 1 [ J Neuroinflammation, 2023, 20(1):91] | PubMed: 37029422 |
Embelin attenuates lipopolysaccharide-induced acute kidney injury through the inhibition of M1 macrophage activation and NF-κB signaling in mice [ Heliyon, 2023, 9(3):e14006] | PubMed: 36938407 |
Citrulline inhibits LPS-induced pyroptosis of RAW264.7 macrophages through NF-κB signaling pathway [ Immun Inflamm Dis, 2023, 11(4):e832] | PubMed: 37102651 |
TAZ ameliorates the microglia-mediated inflammatory response via the Nrf2-ROS-NF-κB pathway [ Mol Ther Nucleic Acids, 2022, 28:435-449] | PubMed: 35505966 |
Spironolactone Ameliorates Senescence and Calcification by Modulating Autophagy in Rat Tendon-Derived Stem Cells via the NF-κB/MAPK Pathway [ Oxid Med Cell Longev, 2021, 2021:5519587] | PubMed: 34306308 |
Betulinic acid promotes the osteogenic differentiation of human periodontal ligament stem cells by upregulating EGR1 [ Acta Biochim Biophys Sin (Shanghai), 2021, gmab111] | PubMed: 34519779 |
Long Noncoding RNA MALAT1 Regulates the Progression of Atherosclerosis by miR-330-5p/NF-κB Signal Pathway [ J Cardiovasc Pharmacol, 2021, 78(2):235-246] | PubMed: 34554676 |
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.