β-Anhydroicaritin

Catalog No.E0246 Batch:E024601

Technical Data

Formula	C₂₁H₂₀O₆
Molecular Weight	368.38	CAS No.	38226-86-7
Solubility (25°C)*	In vitro	DMSO	9 mg/mL (24.43 mM)


* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description	β-Anhydroicaritin is isolated from Boswellia carterii Birdware, has antiosteoporosis, estrogen regulation and antitumor properties.
In vitro	β-Anhydroicaritin is isolated from Boswellia carterii Birdware, has important biological and pharmacological effects, such as antiosteoporosis, estrogen regulation and antitumor properties.^[1]
In vivo	β-Anhydroicaritin ameliorates the degradation of periodontal tissue and inhibits the synthesis and secretion of TNF-α and MMP-3 in diabetic rats.^[2]

Protocol (from reference)

Cell Assay:^{^[1]}	Cell lines Hela, HCC1954 and SK-OV-3 cell lines Concentrations -- Incubation Time -- Method Preylated flavonoid icaritin upon treatment with formic acid under microwave assistance gave another natural product β-anhydroicaritin in good yield (89%). Their cytotoxic potential against three human cancer cell lines (Hela, HCC1954 and SK-OV-3) are evaluated by the standard MTT method with cis-Platin and Paclitaxel as positive control.
Animal Study:^{^[2]}	Animal Models Diabetic rats Dosages 100 mg/kg/day Administration --

Cell Assay:^{^[1]}

Cell lines
Hela, HCC1954 and SK-OV-3 cell lines
Concentrations
--
Incubation Time
--
Method
Preylated flavonoid icaritin upon treatment with formic acid under microwave assistance gave another natural product β-anhydroicaritin in good yield (89%). Their cytotoxic potential against three human cancer cell lines (Hela, HCC1954 and SK-OV-3) are evaluated by the standard MTT method with cis-Platin and Paclitaxel as positive control.

Animal Study:^{^[2]}

Animal Models
Diabetic rats
Dosages
100 mg/kg/day
Administration
--

References

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

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