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Technical Data
| Formula | C19H23N3O.HCl |
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| Molecular Weight | 345.87 | CAS No. | 132-69-4 | |
| Solubility (25°C)* | In vitro | DMSO | 69 mg/mL (199.49 mM) | |
| Water | 69 mg/mL (199.49 mM) | |||
| Ethanol | 69 mg/mL (199.49 mM) | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Benzydamine HCl (AF864) is a topical nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, antipyretic and local anesthetic activity. |
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| In vitro | Benzydamine is structurally unrelated to the corticosteroids. The action of benzydamine may be mediated by the prostaglandin system. The drug may affect formation of thromboxanes and alter biosynthesis of prostaglandin, in doses that can be reached by topical application. Benzydamine displays a stabilizing effect on cell membranes, inhibits degranulation of human polymorphonuclear leukocytes, and inhibits platelet aggregation. Benzydamine may affect aspects of tissue biochemistry relevant to local mechanisms of inflammation and pain. [1] |
| In vivo | Benzydamine significantly lower the incidence of postoperative sore throat (POST). At 6 hours after extubation, the incidence of POST is 17.0%. Spraying benzydamine hydrochloride on the ETT cuff is a simple and effective method to reduce the incidence and severity of POST. [2] |
Protocol (from reference)
References
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
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