Belotecan (CKD-602) hydrochloride

Catalog No.S6631 Batch:S663101

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Technical Data

Formula

C25H28ClN3O4
Molecular Weight 469.96 CAS No. 213819-48-8
Solubility (25°C)* In vitro DMSO 47 mg/mL (100.0 mM)
Water 4 mg/mL (8.51 mM)
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Belotecan (CKD-602) is a potent DNA topoisomerase I inhibitor that exerts a clinical anticancer effect on various types of tumor.
Targets
DNA topoisomerase I [1]
In vitro

CKD-602 promotes pro-apoptotic activity, induces cell-cycle arrest in the G2/M phase and inhibits cancer invasion in cervical cancer[1].

Protocol (from reference)

Cell Assay:

[1]
  • Cell lines

    CaSki, HeLa and SiHa cells

  • Concentrations

    0-150 nM

  • Incubation Time

    48 h

  • Method

    --
Animal Study:

[1]
  • Animal Models

    BALB/c-nude mice subcutaneously injected with CaSki cells

  • Dosages

    25 m/kg

  • Administration

    IV

RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.

SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.