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Technical Data
| Formula | C8H13NO2 |
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| Molecular Weight | 155.19 | CAS No. | 20448-79-7 | |
| Solubility (25°C)* | In vitro | Water | 31 mg/mL (199.75 mM) | |
| DMSO | Insoluble | |||
| Ethanol | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | BCH (2-Aminobicyclo-(2,2,1)-heptane-2-carboxylic acid, LAT1-IN-1) is a selective and competitive inhibitor of system L amino acid transporter 1 (LAT1). BCH (LAT1-IN-1) induces apoptosis in cancer cells. | |
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Protocol (from reference)
Selleck's BCH has been cited by 5 publications
| Tryptophan depletion sensitizes the AHR pathway by increasing AHR expression and GCN2/LAT1-mediated kynurenine uptake, and potentiates induction of regulatory T lymphocytes [ J Immunother Cancer, 2023, 11(6)e006728] | PubMed: 37344101 |
| Tryptophan depletion sensitizes the AHR pathway by increasing AHR expression and GCN2/LAT1-mediated kynurenine uptake, and potentiates induction of regulatory T lymphocytes [ J Immunother Cancer, 2023, 11(6)e006728] | PubMed: 37344101 |
| Methionine orchestrates the metabolism vulnerability in cisplatin resistant bladder cancer microenvironment [ Cell Death Dis, 2023, 14(8):525] | PubMed: 37582769 |
| Methionine orchestrates the metabolism vulnerability in cisplatin resistant bladder cancer microenvironment [ Cell Death Dis, 2023, 14(8):525] | PubMed: 37582769 |
| MAPK signaling regulates c-MYC for melanoma cell adaptation to asparagine restriction [ EMBO Rep, 2021, e51436] | PubMed: 33554439 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.