Bazedoxifene acetate

Catalog No.S2167 Batch:S216704

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Technical Data

Formula

C30H34N2O3.C2H4O2

Molecular Weight 530.65 CAS No. 198481-33-3
Solubility (25°C)* In vitro DMSO 100 mg/mL (188.44 mM)
Ethanol 25 mg/mL (47.11 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description Bazedoxifene acetate is a third generation selective estrogen receptor modulator (SERM).
Targets
estrogen receptor [1]

Protocol (from reference)

Customer Product Validation

Data from [J Med Chem, 2014, 57(3), 632-41]

Selleck's Bazedoxifene acetate has been cited by 4 publications

A compendium of kinetic modulatory profiles identifies ferroptosis regulators [ Nat Chem Biol, 2021, 10.1038/s41589-021-00751-4] PubMed: 33686292
Bazedoxifene inhibits sustained STAT3 activation and increases survival in GBM [ Transl Oncol, 2021, 14(11):101192] PubMed: 34365219
The dysregulated pharmacology of clinically relevant ESR1 mutants is normalized by ligand-activated WT receptor. [ Mol Cancer Ther, 2020, 7 pii: molcanther] PubMed: 32381587
Repurposing the Selective Estrogen Receptor Modulator bazedoxifene to Suppress Gastrointestinal Cancer Growth [ EMBO Mol Med, 2019, 11(4):e9539] PubMed: 30885958

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.