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Technical Data
| Formula | C34H40N2O18 |
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| Molecular Weight | 764.68 | CAS No. | 126150-97-8 | |
| Solubility (25°C)* | In vitro | DMSO | 33 mg/mL (43.15 mM) | |
| Water | Insoluble | |||
| Ethanol | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | BAPTA-AM is a selective, membrane-permeable calcium chelator. |
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| In vitro | BAPTA-AM, as an intracellular calcium chelator, induces delayed necrosis by lipoxygenase-mediated free radicals in mouse cortical cultures. [1] BAPTA-AM exerts an open channel blocking effect on hERG, hKv1.3 and hKv1.5 channels with IC50 of 1.3, 1.45 and 1.23 μM in HEK 293 cells. [2] |
| In vivo | BAPTA-AM abolishes the UDCA- and TUDCA-induced increases in Ca2+ levels or Ca2+-Dependent PKC-α phosphorylation, and neutralizes the cytoprotective effects of UDCA and TUDCA on the vagotomy-induced damage of the biliary tree in the BDL rats. [3] |
Protocol (from reference)
| Animal Study: |
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References
Customer Product Validation
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, , J Cell Mol Med, 2017, 21(7):1373-1387
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Data from [Data independently produced by , , Acta Pharm Sin B, 2018, 8(6):909-918]
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Data from [Data independently produced by , , CNS Neurosci Ther, 2017, 23(4):291-300]
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Data from [Data independently produced by , , Exp Cell Res, 2017, 358(2):360-368]
Selleck's BAPTA-AM has been cited by 80 publications
| TRPM2-mediated feed-forward loop promotes chondrocyte damage in osteoarthritis via calcium-cGAS-STING-NF-κB pathway [ J Adv Res, 2024, S2090-1232(24)00499-5] | PubMed: 39505144 |
| Ammonia stress-induced heat shock factor 1 enhances white spot syndrome virus infection by targeting the interferon-like system in shrimp [ mBio, 2024, e0313623.] | PubMed: 38358252 |
| High-affinity tuning of single fluorescent protein-type indicators by flexible linker length optimization in topology mutant [ Commun Biol, 2024, 7(1):705] | PubMed: 38851844 |
| Matrix stiffness aggravates osteoarthritis progression through H3K27me3 demethylation induced by mitochondrial damage [ iScience, 2024, 27(8):110507] | PubMed: 39156637 |
| Haemolysins are essential to the pathogenicity of deep-sea Vibrio fluvialis [ iScience, 2024, 27(5):109558] | PubMed: 38650982 |
| ABT‑737 increases cisplatin sensitivity through the ROS‑ASK1‑JNK MAPK signaling axis in human ovarian cancer cisplatin‑resistant A2780/DDP cells [ Oncol Rep, 2024, 52(3)122] | PubMed: 39054955 |
| The delta subunit of the GABAA receptor is necessary for the GPT2-promoted breast cancer metastasis [ Theranostics, 2023, 13(4):1355-1369] | PubMed: 36923530 |
| Uptake-independent killing of macrophages by extracellular Mycobacterium tuberculosis aggregates [ EMBO J, 2023, e113490.] | PubMed: 36920246 |
| Uptake-independent killing of macrophages by extracellular Mycobacterium tuberculosis aggregates [ EMBO J, 2023, 42(9):e113490] | PubMed: 36920246 |
| CRTAC1 enhances the chemosensitivity of non-small cell lung cancer to cisplatin by eliciting RyR-mediated calcium release and inhibiting Akt1 expression [ Cell Death Dis, 2023, 10.1038/s41419-023-06088-1] | PubMed: 37633993 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.