Balixafortide (POL6326)

Catalog No.S9725 Batch:S972501

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Technical Data

Formula

C84H118N24O21S2
Molecular Weight 1864.11 CAS No. 1051366-32-5
Solubility (25°C)* In vitro Water 100 mg/mL (53.64 mM)
 
 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description

Balixafortide (POL6326) is an orally bioavailable peptidic CXC chemokine receptor 4 (CXCR4) antagonist.
Targets
CXCR4 [1]
In vivo

POL6326 enhances systolic function in a porcine closed-chest model of reperfused acute MI. POL6326 mobilizes Treg cells, enhances Treg cell recruitment to the infarct, attenuates tumor necrosis factor expression in monocytes and macrophages in the infarcted region, enhances infarct border-zone capillarization, reduces infarct scar size, and attenuates LV remodeling and systolic dysfunction in mice.[2]

Protocol (from reference)

Animal Study:

[2]
  • Animal Models

    C57BL/6NCrl wild-type (WT) mice, domestic (DanBred hybrid) female pigs

  • Dosages

    8 mg/kg, 3 mg/kg

  • Administration

    IV

RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.