Bakuchiol

Catalog No.S3813 Batch:S381301

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Technical Data

Formula

C18H24O
Molecular Weight 256.38 CAS No. 10309-37-2
Solubility (25°C)* In vitro  
 
 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Biological Activity

Description Bakuchiol ((S)-(+)-Bakuchiol) is a meroterpene phenol abundant in seeds and leaves of the plant Psoralea corylifolia. It has anti-inflammatory and antimicrobial activities., Bakuchiol ((S)-(+)-Bakuchiol) is a meroterpene phenol abundant in seeds and leaves of the plant Psoralea corylifolia. It has anti-inflammatory and antimicrobial activities.
In vitro Bakuchiol inhibits EGF-induced signaling pathways downstream of Hck, Blk and p38 MAPK, including the MEK/ERKs, p38 MAPK/MSK1 and AKT/p70S6K pathways. Bakuchiol decreases viability and inhibits anchorage-independent growth of A431 human epithelial carcinoma cells. It also inhibits the proliferation of A549 human lung adenocarcinoma cells, SK-MEL-2 human melanoma cells and B16 mouse melanoma cells by inducing apoptosis[1].
In vivo Bakuchiol reduces A431 xenograft tumor growth in an in vivo mouse model[1]. Bakuchiol treatment attenuates acute lung injury following sepsis by suppressing inflammation, oxidative stress, and endothelial barrier disruption[2].
Density 0.96 g/mL

Protocol (from reference)

Cell Assay:

[1]
  • Cell lines

    HaCaT and JB6 P+ cells

  • Concentrations

    0, 5, 10, and 20 μM

  • Incubation Time

    1 h

  • Method

    Cells (1.5 × 106) are cultured in 100-mm dishes for 48 h, and then serum starved in 0.1% FBS-MEM for 24 h. The cells are then treated with bakuchiol (0, 5, 10, and 20 μM) for 1 h before exposure to 10 ng/ml EGF for an additional 30 min. Cells are harvested and disrupted with lysis buffer before protein concentration is measured using a dye-binding protein assay kit.
Animal Study:

[1]
  • Animal Models

    6-week-old, BALB/c-nu mice

  • Dosages

    10 or 40 mg/kg

  • Administration

    i.p.

Selleck's Bakuchiol has been cited by 1 publication

Effects of Bakuchiol on chondrocyte proliferation via the PI3K-Akt and ERK1/2 pathways mediated by the estrogen receptor for promotion of the regeneration of knee articular cartilage defects. [ Cell Prolif, 2019, 52(5):e12666] PubMed: 31407423

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.