Avacopan

Catalog No.S0474 Batch:S047401

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Technical Data

Formula

C33H35F4N3O2
Molecular Weight 581.64 CAS No. 1346623-17-3
Solubility (25°C)* In vitro DMSO 100 mg/mL (171.92 mM)
Ethanol 20 mg/mL (34.38 mM)
Water Insoluble
In vivo (Add solvents to the product individually and in order)
Clear solution
5%DMSO 40%PEG300 5%Tween80 50%ddH2O
0.6mg/ml Taking the 1 mL working solution as an example, add 50 μL of 12 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results. 
Clear solution
5% DMSO 95% Corn oil
0.6mg/ml Taking the 1 mL working solution as an example, add 50 μL of 12 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results. 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Avacopan is an orally administered and selective C5a receptor (C5aR) antagonist.
Targets
C5aR [1]
In vitro

Avacopan (CCX168) is an orally administered and selective C5a receptor (C5aR) antagonist.

Protocol (from reference)

Cell Assay:

[2]
  • Cell lines

    RAW 264.7 cells

  • Concentrations

    1 µM

  • Incubation Time

    24 h

  • Method

    Cells were treated with indicated concentrations of drug for 24 h.
Animal Study:

[3]
  • Animal Models

    C57B6/6J (B6) and C3H/HeJ mice

  • Dosages

    30 mg/kg

  • Administration

    o.g.

Selleck's Avacopan has been cited by 2 publications

Cathepsin C inhibition reduces neutrophil serine protease activity and improves activated neutrophil-mediated disorders [ Nat Commun, 2024, 15(1):6519] PubMed: 39174512
Paclitaxel binds and activates C5aR1: A new potential therapeutic target for the prevention of chemotherapy-induced peripheral neuropathy and hypersensitivity reactions [ Cell Death Dis, 2022, 13(5):500] PubMed: 35614037

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.