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Technical Data
| Formula | C20H34AuO9PS |
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| Molecular Weight | 678.48 | CAS No. | 34031-32-8 | |
| Solubility (25°C)* | In vitro | DMSO | 100 mg/mL (147.38 mM) | |
| Ethanol | 100 mg/mL (147.38 mM) | |||
| Water | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Preparing Stock Solutions
Biological Activity
| Description | Auranofin is an inhibitor of thioredoxin reductase (TrxR) with IC50 of 88 nM for purified H. pylori TrxR in cell-free assay. Auranofin has anti-cancer activity and can completely inhibit bacterial growth at 1.2 μM. Auranofin is an FDA-approved gold-containing compound used for the treatment of rheumatoid arthritis. | ||
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| Targets |
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| In vitro | Auranofin (Ridaura, SKF-39162) is an inhibitor of thioredoxin reductase (TrxR) with IC50 of 88 nM for purified H. pylori TrxR in cell-free assay. |
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| In vivo | Auranofin is a small molecule inhibitor of NONO that suppressed GBM tumor growth in an orthotopic xenograft model in mice. |
Protocol (from reference)
| Animal Study: |
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References
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Selleck's Auranofin has been cited by 3 publications
| Repurposing FDA-Approved Drugs for Temozolomide-Resistant IDH1 Mutant Glioma Using High-Throughput Miniaturized Screening on Droplet Microarray Chip [ Adv Healthc Mater, 2023, e2300591.] | PubMed: 37162029 |
| Targeting the splicing factor NONO inhibits GBM progression through GPX1 intron retention [ Theranostics, 2022, 12(12):5451-5469] | PubMed: 35910786 |
| [ Oncotarget, 2018, ] | PubMed: 29599910 |
RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.